ER stress in antigen-presenting cells promotes NKT cell activation through endogenous neutral lipids.
Govindarajan S, Verheugen E, Venken K, Gaublomme D, Maelegheer M, Cloots E, Gysens F, De Geest BG, Cheng TY, Moody DB, Janssens S, Drennan M, Elewaut D.
Govindarajan S, et al. Among authors: drennan m.
EMBO Rep. 2020 Jun 4;21(6):e48927. doi: 10.15252/embr.201948927. Epub 2020 May 3.
EMBO Rep. 2020.
PMID: 32363653
Free PMC article.
This pathway relies on the presence of two transducers of the unfolded protein response: inositol-requiring enzyme-1a (IRE1alpha) and protein kinase R-like ER kinase (PERK). Surprisingly, the neutral but not the polar lipids generated within APCs undergoing ER stress are c …
This pathway relies on the presence of two transducers of the unfolded protein response: inositol-requiring enzyme-1a (IRE1alpha) and protei …