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7-Dehydrocholesterol is an endogenous suppressor of ferroptosis.
Freitas FP, Alborzinia H, Dos Santos AF, Nepachalovich P, Pedrera L, Zilka O, Inague A, Klein C, Aroua N, Kaushal K, Kast B, Lorenz SM, Kunz V, Nehring H, Xavier da Silva TN, Chen Z, Atici S, Doll SG, Schaefer EL, Ekpo I, Schmitz W, Horling A, Imming P, Miyamoto S, Wehman AM, Genaro-Mattos TC, Mirnics K, Kumar L, Klein-Seetharaman J, Meierjohann S, Weigand I, Kroiss M, Bornkamm GW, Gomes F, Netto LES, Sathian MB, Konrad DB, Covey DF, Michalke B, Bommert K, Bargou RC, Garcia-Saez A, Pratt DA, Fedorova M, Trumpp A, Conrad M, Friedmann Angeli JP. Freitas FP, et al. Among authors: dos santos af. Nature. 2024 Feb;626(7998):401-410. doi: 10.1038/s41586-023-06878-9. Epub 2024 Jan 31. Nature. 2024. PMID: 38297129
LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma.
Alborzinia H, Chen Z, Yildiz U, Freitas FP, Vogel FCE, Varga JP, Batani J, Bartenhagen C, Schmitz W, Büchel G, Michalke B, Zheng J, Meierjohann S, Girardi E, Espinet E, Flórez AF, Dos Santos AF, Aroua N, Cheytan T, Haenlin J, Schlicker L, Xavier da Silva TN, Przybylla A, Zeisberger P, Superti-Furga G, Eilers M, Conrad M, Fabiano M, Schweizer U, Fischer M, Schulze A, Trumpp A, Friedmann Angeli JP. Alborzinia H, et al. Among authors: dos santos af. EMBO Mol Med. 2023 Aug 7;15(8):e18014. doi: 10.15252/emmm.202318014. Epub 2023 Jul 12. EMBO Mol Med. 2023. PMID: 37435859 Free PMC article.
The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2.
Kreß JKC, Jessen C, Hufnagel A, Schmitz W, Xavier da Silva TN, Ferreira Dos Santos A, Mosteo L, Goding CR, Friedmann Angeli JP, Meierjohann S. Kreß JKC, et al. Among authors: ferreira dos santos a. Cell Rep. 2023 Jul 25;42(7):112724. doi: 10.1016/j.celrep.2023.112724. Epub 2023 Jul 4. Cell Rep. 2023. PMID: 37410595 Free article.
Thiol starvation triggers melanoma state switching in an ATF4 and NRF2-dependent manner.
Meinert M, Jessen C, Hufnagel A, Kreß JKC, Burnworth M, Däubler T, Gallasch T, Xavier da Silva TN, Dos Santos AF, Ade CP, Schmitz W, Kneitz S, Friedmann Angeli JP, Meierjohann S. Meinert M, et al. Among authors: dos santos af. Redox Biol. 2024 Apr;70:103011. doi: 10.1016/j.redox.2023.103011. Epub 2023 Dec 27. Redox Biol. 2024. PMID: 38219574 Free PMC article.
Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness.
Moreira Franco YE, Alves MJ, Uno M, Moretti IF, Trombetta-Lima M, de Siqueira Santos S, Dos Santos AF, Arini GS, Baptista MS, Lerario AM, Oba-Shinjo SM, Marie SKN. Moreira Franco YE, et al. Among authors: dos santos af. Cancer Metab. 2021 Apr 28;9(1):18. doi: 10.1186/s40170-021-00255-8. Cancer Metab. 2021. PMID: 33910646 Free PMC article.
Integrated Proteomics Reveals Apoptosis-related Mechanisms Associated with Placental Malaria.
Kawahara R, Rosa-Fernandes L, Dos Santos AF, Bandeira CL, Dombrowski JG, Souza RM, Da Fonseca MP, Festuccia WT, Labriola L, Larsen MR, Marinho CRF, Palmisano G. Kawahara R, et al. Among authors: dos santos af. Mol Cell Proteomics. 2019 Feb;18(2):182-199. doi: 10.1074/mcp.RA118.000907. Epub 2018 Sep 21. Mol Cell Proteomics. 2019. PMID: 30242111 Free PMC article.
Glypican-3 induces a mesenchymal to epithelial transition in human breast cancer cells.
Castillo LF, Tascón R, Lago Huvelle MR, Novack G, Llorens MC, Dos Santos AF, Shortrede J, Cabanillas AM, Bal de Kier Joffé E, Labriola L, Peters MG. Castillo LF, et al. Among authors: dos santos af. Oncotarget. 2016 Sep 13;7(37):60133-60154. doi: 10.18632/oncotarget.11107. Oncotarget. 2016. PMID: 27507057 Free PMC article.