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2023 | 4 |
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Page 1
Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation.
ACS Chem Neurosci. 2023 Nov 1;14(21):3913-3927. doi: 10.1021/acschemneuro.3c00464. Epub 2023 Oct 11.
ACS Chem Neurosci. 2023.
PMID: 37818657
Free article.
5-Nitro-1,2-benzothiazol-3-amine and N-Ethyl-1-[(ethylcarbamoyl)(5-nitro-1,2-benzothiazol-3-yl)amino]formamide Modulate α-Synuclein and Tau Aggregation.
Ramirez E, Ganegamage SK, Elbatrawy AA, Alnakhala H, Shimanaka K, Tripathi A, Min S, Rochet JC, Dettmer U, Fortin JS.
Ramirez E, et al. Among authors: alnakhala h.
ACS Omega. 2023 May 23;8(22):20102-20115. doi: 10.1021/acsomega.3c02668. eCollection 2023 Jun 6.
ACS Omega. 2023.
PMID: 37305264
Free PMC article.
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Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.
Tripathi A, Alnakhala H, Terry-Kantor E, Newman A, Liu L, Imberdis T, Fanning S, Nuber S, Ramalingam N, Selkoe D, Dettmer U.
Tripathi A, et al. Among authors: alnakhala h.
J Neurosci. 2022 Mar 9;42(10):2116-2130. doi: 10.1523/JNEUROSCI.1881-21.2022. Epub 2022 Jan 27.
J Neurosci. 2022.
PMID: 35086904
Free PMC article.
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Adding hydrophobicity or positive charges to the cytosolic half of the α-synuclein 3-11 helix increases membrane association and S129 phosphorylation.
Shimanaka K, Shi B, Brontesi L, Alnakhala H, Jayanthi V, Subramanian K, Ramalingam N, Tripathi A, Dettmer U.
Shimanaka K, et al. Among authors: alnakhala h.
FEBS Lett. 2024 Jan;598(2):210-219. doi: 10.1002/1873-3468.14773. Epub 2023 Nov 21.
FEBS Lett. 2024.
PMID: 37989349
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1,4-Diurea- and 1,4-Dithiourea-Substituted Aromatic Derivatives Selectively Inhibit α-Synuclein Oligomer Formation In Vitro.
Ganegamage SK, Ramirez E, Alnakhala H, Tripathi A, Nguyen CCD, Zami A, Ostafe R, Tian S, Dettmer U, Fortin JS.
Ganegamage SK, et al. Among authors: alnakhala h.
ACS Omega. 2023 Dec 19;9(1):1216-1229. doi: 10.1021/acsomega.3c07453. eCollection 2024 Jan 9.
ACS Omega. 2023.
PMID: 38222653
Free PMC article.
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Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and α-synuclein fibrils.
Elbatrawy AA, Ademoye TA, Alnakhala H, Tripathi A, Zami A, Ostafe R, Dettmer U, Fortin JS.
Elbatrawy AA, et al. Among authors: alnakhala h.
Bioorg Med Chem. 2024 Feb 15;100:117613. doi: 10.1016/j.bmc.2024.117613. Epub 2024 Jan 28.
Bioorg Med Chem. 2024.
PMID: 38330847
Free PMC article.
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