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O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology.
Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR. Balana AT, et al. Among authors: mahul mellier al. Nat Chem Biol. 2024 May;20(5):646-655. doi: 10.1038/s41589-024-01551-2. Epub 2024 Feb 12. Nat Chem Biol. 2024. PMID: 38347213 Free PMC article.
Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity.
Lashuel HA, Mahul-Mellier AL, Novello S, Hegde RN, Jasiqi Y, Altay MF, Donzelli S, DeGuire SM, Burai R, Magalhães P, Chiki A, Ricci J, Boussouf M, Sadek A, Stoops E, Iseli C, Guex N. Lashuel HA, et al. Among authors: mahul mellier al. NPJ Parkinsons Dis. 2022 Oct 20;8(1):136. doi: 10.1038/s41531-022-00388-7. NPJ Parkinsons Dis. 2022. PMID: 36266318 Free PMC article.
Alix and ALG-2 make a link between endosomes and neuronal death.
Mahul-Mellier AL, Strappazzon F, Chatellard-Causse C, Blot B, Béal D, Torch S, Hemming F, Petiot A, Verna JM, Fraboulet S, Sadoul R. Mahul-Mellier AL, et al. Biochem Soc Trans. 2009 Feb;37(Pt 1):200-3. doi: 10.1042/BST0370200. Biochem Soc Trans. 2009. PMID: 19143631 Review.
O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology.
Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR. Balana AT, et al. Among authors: mahul mellier al. bioRxiv [Preprint]. 2023 Mar 7:2023.03.07.531573. doi: 10.1101/2023.03.07.531573. bioRxiv. 2023. PMID: 36945566 Free PMC article. Updated. Preprint.
Amyloid single-cell cytotoxicity assays by nanomotion detection.
Ruggeri FS, Mahul-Mellier AL, Kasas S, Lashuel HA, Longo G, Dietler G. Ruggeri FS, et al. Among authors: mahul mellier al. Cell Death Discov. 2017 Aug 21;3:17053. doi: 10.1038/cddiscovery.2017.53. eCollection 2017. Cell Death Discov. 2017. PMID: 28845298 Free PMC article.
A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity.
Kumar ST, Mahul-Mellier AL, Hegde RN, Rivière G, Moons R, Ibáñez de Opakua A, Magalhães P, Rostami I, Donzelli S, Sobott F, Zweckstetter M, Lashuel HA. Kumar ST, et al. Among authors: mahul mellier al. Sci Adv. 2022 Apr 29;8(17):eabn0044. doi: 10.1126/sciadv.abn0044. Epub 2022 Apr 29. Sci Adv. 2022. PMID: 35486726 Free PMC article.
24 results