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12 results

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Page 1
BCL-XL inhibitors enhance the apoptotic efficacy of BRAF inhibitors in BRAFV600E colorectal cancer.
Jenkins LJ, Luk IY, Chionh F, Tan T, Needham K, Ayton J, Reehorst CM, Vukelic N, Sieber OM, Mouradov D, Gibbs P, Williams DS, Tebbutt NC, Desai J, Hollande F, Dhillon AS, Lee EF, Merino D, Fairlie WD, Mariadason JM. Jenkins LJ, et al. Among authors: luk iy. Cell Death Dis. 2024 Mar 1;15(3):183. doi: 10.1038/s41419-024-06478-z. Cell Death Dis. 2024. PMID: 38429301 Free PMC article.
Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis.
Nightingale R, Reehorst CM, Vukelic N, Papadopoulos N, Liao Y, Guleria S, Bell C, Vaillant F, Paul S, Luk IY, Dhillon AS, Jenkins LJ, Morrow RJ, Jackling FC, Chand AL, Chisanga D, Chen Y, Williams DS, Anderson RL, Ellis S, Meikle PJ, Shi W, Visvader JE, Pal B, Mariadason JM. Nightingale R, et al. Among authors: luk iy. Dev Cell. 2024 Aug 5;59(15):1988-2004.e11. doi: 10.1016/j.devcel.2024.04.022. Epub 2024 May 22. Dev Cell. 2024. PMID: 38781975 Free article.
BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking.
Tran S, Juliani J, Harris TJ, Evangelista M, Ratcliffe J, Ellis SL, Baloyan D, Reehorst CM, Nightingale R, Luk IY, Jenkins LJ, Ghilas S, Yakou MH, Inguanti C, Johnson C, Buchert M, Lee JC, De Cruz P, Duszyc K, Gleeson PA, Kile BT, Mielke LA, Yap AS, Mariadason JM, Fairlie WD, Lee EF. Tran S, et al. Among authors: luk iy. Commun Biol. 2024 Feb 20;7(1):209. doi: 10.1038/s42003-024-05890-7. Commun Biol. 2024. PMID: 38378743 Free PMC article.
Intestinal-specific Hdac3 deletion increases susceptibility to colitis and small intestinal tumor development in mice fed a high-fat diet.
Ng I, Luk IY, Nightingale R, Reehorst CM, Dávalos-Salas M, Jenkins LJ, Fong C, Williams DS, Watt MJ, Dhillon AS, Mariadason JM. Ng I, et al. Among authors: luk iy. Am J Physiol Gastrointest Liver Physiol. 2023 Dec 1;325(6):G508-G517. doi: 10.1152/ajpgi.00160.2023. Epub 2023 Oct 3. Am J Physiol Gastrointest Liver Physiol. 2023. PMID: 37788331
Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression.
Luk IY, Jenkins LJ, Schoffer KL, Ng I, Tse JWT, Mouradov D, Kaczmarczyk S, Nightingale R, Burrows AD, Anderson RL, Arango D, Dopeso H, Croft L, Richardson MF, Sieber OM, Liao Y, Mooi JK, Vukelic N, Reehorst CM, Afshar-Sterle S, Whitehall VLJ, Fennell L, Abud HE, Tebbutt NC, Phillips WA, Williams DS, Shi W, Mielke LA, Ernst M, Dhillon AS, Clemons NJ, Mariadason JM. Luk IY, et al. Cell Death Differ. 2022 Nov;29(11):2288-2302. doi: 10.1038/s41418-022-01016-w. Epub 2022 May 23. Cell Death Differ. 2022. PMID: 35606410 Free PMC article.
Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death.
Jenkins LJ, Luk IY, Fairlie WD, Lee EF, Palmieri M, Schoffer KL, Tan T, Ng I, Vukelic N, Tran S, Tse JWT, Nightingale R, Alam Z, Chionh F, Iatropoulos G, Ernst M, Afshar-Sterle S, Desai J, Gibbs P, Sieber OM, Dhillon AS, Tebbutt NC, Mariadason JM. Jenkins LJ, et al. Among authors: luk iy. Mol Cancer Ther. 2023 Jan 3;22(1):52-62. doi: 10.1158/1535-7163.MCT-22-0101. Mol Cancer Ther. 2023. PMID: 36343387 Free PMC article.
EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis.
Reehorst CM, Nightingale R, Luk IY, Jenkins L, Koentgen F, Williams DS, Darido C, Tan F, Anderton H, Chopin M, Schoffer K, Eissmann MF, Buchert M, Mouradov D, Sieber OM, Ernst M, Dhillon AS, Mariadason JM. Reehorst CM, et al. Among authors: luk iy. Development. 2021 Jun 15;148(12):dev199542. doi: 10.1242/dev.199542. Epub 2021 Jun 28. Development. 2021. PMID: 34180969
Rapid Resistance of FGFR-driven Gastric Cancers to Regorafenib and Targeted FGFR Inhibitors can be Overcome by Parallel Inhibition of MEK.
Lau DK, Luk IY, Jenkins LJ, Martin A, Williams DS, Schoffer KL, Chionh F, Buchert M, Sjoquist K, Boussioutas A, Hayes SA, Ernst M, Weickhardt AJ, Pavlakis N, Tebbutt NC, Mariadason JM. Lau DK, et al. Among authors: luk iy. Mol Cancer Ther. 2021 Apr;20(4):704-715. doi: 10.1158/1535-7163.MCT-20-0836. Epub 2021 Feb 9. Mol Cancer Ther. 2021. PMID: 33563752 Clinical Trial.
12 results