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Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation.
Sci Signal. 2024 Feb 27;17(825):eadf2670. doi: 10.1126/scisignal.adf2670. Epub 2024 Feb 27.
Sci Signal. 2024.
PMID: 38412255
Free PMC article.
Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype.
Madsen RR, Erickson EC, Rueda OM, Robin X, Caldas C, Toker A, Semple RK, Vanhaesebroeck B.
Madsen RR, et al. Among authors: erickson ec.
PLoS Genet. 2021 Nov 11;17(11):e1009876. doi: 10.1371/journal.pgen.1009876. eCollection 2021 Nov.
PLoS Genet. 2021.
PMID: 34762647
Free PMC article.
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Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling.
You I, Erickson EC, Donovan KA, Eleuteri NA, Fischer ES, Gray NS, Toker A.
You I, et al. Among authors: erickson ec.
Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7. doi: 10.1016/j.chembiol.2019.11.014. Epub 2019 Dec 16.
Cell Chem Biol. 2020.
PMID: 31859249
Free PMC article.
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Can Improved Use of Biomarkers Alter the Fate of PI3K Pathway Inhibitors in the Clinic?
Erickson EC, Toker A.
Erickson EC, et al.
Cancer Res. 2021 Dec 15;81(24):6083-6086. doi: 10.1158/0008-5472.CAN-21-2035.
Cancer Res. 2021.
PMID: 34911776
Free PMC article.
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