Extracellular vesicles in the treatment of oxidative stress injury: global research status and trends

Wenwen Zhang; Bin Gan; Tingyu Wang; Xiangjie Yang; Yuanye Xue; Yuanqing Zhong; Xintong He; Xinsheng Peng; Yanfang Zhou; Xiaoyan Cheng

doi:10.3389/fmolb.2023.1273113

Extracellular vesicles in the treatment of oxidative stress injury: global research status and trends

Front Mol Biosci. 2024 Feb 15:10:1273113. doi: 10.3389/fmolb.2023.1273113. eCollection 2023.

Authors

Wenwen Zhang^#¹, Bin Gan^#², Tingyu Wang¹, Xiangjie Yang³, Yuanye Xue¹, Yuanqing Zhong⁴, Xintong He⁴, Xinsheng Peng^#^{5

6}, Yanfang Zhou^#¹, Xiaoyan Cheng^#⁴

Affiliations

¹ Department of Pathophysiology, Guangdong Medical University, Dongguan, China.
² The Third Affiliated Hospital of Guangdong Medical University, Fo Shan, China.
³ School of Public Health, Guangdong Medical University, Dongguan, China.
⁴ The Second Clinical Medical College, Guangdong Medical University, Dongguan, China.
⁵ School of Pharmacy, Guangdong Medical University, Dongguan, China.
⁶ Institute of Marine Medicine, Guangdong Medical University, Zhanjiang, China.

^# Contributed equally.

Abstract

Objective: The aim of this study was to conduct a bibliometric analysis of the literature on "Extracellular Vesicles in the Treatment of Oxidative Stress Injury" and to reveal its current status, hot spots and trends. Methods: The relevant literature was obtained from the Web of Science Core Collection (WoSCC) on 29 April 2023. We performed clustering and partnership analysis of authors, institutions, countries, references and keywords in the literature through CiteSpace software and the bibliometric online analysis platform and mapped the relevant knowledge maps. Results: A total of 1,321 relevant publications were included in the bibliometric analysis, with the number of publications in this field increasing year by year. These included 944 "articles" and 377 "reviews". The maximum number of publications published in China is 512, and the maximum number of highly cited publications published in the United States is 20. Based on CiteSpace, the country collaboration network map shows close and stable collaboration among high-productivity countries. Based on WoSCC, there are 1706 relevant research institutions and 119 highly cited elite institutions, among which Kaohsing Chang Gung Men Hosp has the most extensive influence. Studies related to "Extracellular Vesicles in the Treatment of Oxidative Stress Injury" have been published in 548 journals. The keywords of the publications show the main research areas and breakthroughs. Based on WoSCC, the keywords of the research area "Extracellular Vesicles in the Treatment of Oxidative Stress Injury" were found to be as follows: exosome(s), extracellular vesicle(s), oxidative stress, inflammation, mesenchymal stem cells, apoptosis, microRNA (miRNA), mitochondria, biomarker, autophagy, angiogenesis and Alzheimer's disease. Analysis showed that "mesenchymal stem cells", "microRNA", "autophagy", "histology" and "therapeutic" emerged as highly explosive keywords. Conclusion: This study is the first to use visual software and data mining to assess the literature in the field of "Extracellular Vesicles in the Treatment of Oxidative Stress Injury". The research history, research status and direction in this field provide a theoretical basis for its scientific research.

Keywords: Exosomes; bibliometrics; cluster analysis; extracellular vesicles; oxidative Stress.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Our work described in the present manuscript is supported by research grants from Guangdong Provincial Natural Science Foundation, Guangdong, China, No. 2021A1515012437 and Guangdong Provincial Scientific Research Project, Guangdong Provincial Department of Education, No. 2021KTSCX040, Guangdong, China. And this research received funding from the Discipline construction project of Guangdong Medical University (2021ZDZX2039, 1019K20220003).