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Mutant SF3B1 promotes malignancy in PDAC.
Simmler P, Ioannidi EI, Mengis T, Marquart KF, Asawa S, Van-Lehmann K, Kahles A, Thomas T, Schwerdel C, Aceto N, Rätsch G, Stoffel M, Schwank G. Simmler P, et al. Elife. 2023 Oct 12;12:e80683. doi: 10.7554/eLife.80683. Elife. 2023. PMID: 37823551 Free PMC article.
Enhancing prime editor activity by directed protein evolution in yeast.
Weber Y, Böck D, Ivașcu A, Mathis N, Rothgangl T, Ioannidi EI, Blaudt AC, Tidecks L, Vadovics M, Muramatsu H, Reichmuth A, Marquart KF, Kissling L, Pardi N, Jinek M, Schwank G. Weber Y, et al. Among authors: marquart kf. Nat Commun. 2024 Mar 7;15(1):2092. doi: 10.1038/s41467-024-46107-z. Nat Commun. 2024. PMID: 38453904 Free PMC article.
SF3B1 facilitates HIF1-signaling and promotes malignancy in pancreatic cancer.
Simmler P, Cortijo C, Koch LM, Galliker P, Angori S, Bolck HA, Mueller C, Vukolic A, Mirtschink P, Christinat Y, Davidson NR, Lehmann KV, Pellegrini G, Pauli C, Lenggenhager D, Guccini I, Ringel T, Hirt C, Marquart KF, Schaefer M, Rätsch G, Peter M, Moch H, Stoffel M, Schwank G. Simmler P, et al. Cell Rep. 2022 Aug 23;40(8):111266. doi: 10.1016/j.celrep.2022.111266. Cell Rep. 2022. PMID: 36001976 Free article.
Predicting prime editing efficiency and product purity by deep learning.
Mathis N, Allam A, Kissling L, Marquart KF, Schmidheini L, Solari C, Balázs Z, Krauthammer M, Schwank G. Mathis N, et al. Nat Biotechnol. 2023 Aug;41(8):1151-1159. doi: 10.1038/s41587-022-01613-7. Epub 2023 Jan 16. Nat Biotechnol. 2023. PMID: 36646933 Free PMC article.