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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
1958 1
1959 2
1963 1
1964 1
1969 1
1973 1
1974 2
1975 12
1976 8
1977 8
1978 6
1979 4
1980 1
1981 5
1982 8
1983 6
1984 8
1985 15
1986 4
1987 7
1988 9
1989 24
1990 23
1991 30
1992 34
1993 48
1994 54
1995 54
1996 63
1997 86
1998 95
1999 97
2000 101
2001 114
2002 108
2003 126
2004 189
2005 211
2006 280
2007 295
2008 323
2009 389
2010 463
2011 545
2012 592
2013 645
2014 769
2015 852
2016 922
2017 1001
2018 1239
2019 1403
2020 1462
2021 1609
2022 1862
2023 1982
2024 1010
2025 2

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17,166 results

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Page 1
Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.
Wang L, Wu D, Robinson CV, Wu H, Fu TM. Wang L, et al. Among authors: wu h, wu d. Mol Cell. 2020 Nov 5;80(3):501-511.e3. doi: 10.1016/j.molcel.2020.09.029. Epub 2020 Oct 15. Mol Cell. 2020. PMID: 33065002 Free PMC article.
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V(1) complex for ATP hydrolysis and a membrane-embedded V(o) complex for proton transfer. ...The glycolipids and the glycosylated V …
Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton pumps comprised of a cytoplasmic V(1) …
A structural atlas of druggable sites on Na(v) channels.
Li Z, Wu Q, Yan N. Li Z, et al. Among authors: wu q. Channels (Austin). 2024 Dec;18(1):2287832. doi: 10.1080/19336950.2023.2287832. Epub 2023 Nov 30. Channels (Austin). 2024. PMID: 38033122 Free PMC article. Review.
Voltage-gated sodium (Na(v)) channels govern membrane excitability by initiating and propagating action potentials. ...In this review, we will provide an overview of the recent advances in structural pharmacology of Na(v) channels, encompassing the structural map fo …
Voltage-gated sodium (Na(v)) channels govern membrane excitability by initiating and propagating action potentials. ...In this review …
Dual inhibition of alpha(v)beta(6) and alpha(v)beta(1) reduces fibrogenesis in lung tissue explants from patients with IPF.
Decaris ML, Schaub JR, Chen C, Cha J, Lee GG, Rexhepaj M, Ho SS, Rao V, Marlow MM, Kotak P, Budi EH, Hooi L, Wu J, Fridlib M, Martin SP, Huang S, Chen M, Muñoz M, Hom TF, Wolters PJ, Desai TJ, Rock F, Leftheris K, Morgans DJ, Lepist EI, Andre P, Lefebvre EA, Turner SM. Decaris ML, et al. Among authors: wu j. Respir Res. 2021 Oct 19;22(1):265. doi: 10.1186/s12931-021-01863-0. Respir Res. 2021. PMID: 34666752 Free PMC article.
RATIONALE: alpha(v) integrins, key regulators of transforming growth factor-beta activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (alpha(v)beta(6)) and fibroblasts (alpha(v)beta(1)) in fibrotic lu …
RATIONALE: alpha(v) integrins, key regulators of transforming growth factor-beta activation and fibrogenesis in in vivo models of pul …
Crystal structure of semisynthetic obelin-v.
Larionova MD, Wu L, Eremeeva EV, Natashin PV, Gulnov DV, Nemtseva EV, Liu D, Liu ZJ, Vysotski ES. Larionova MD, et al. Among authors: wu l. Protein Sci. 2022 Feb;31(2):454-469. doi: 10.1002/pro.4244. Epub 2021 Nov 29. Protein Sci. 2022. PMID: 34802167 Free PMC article.
Although Ca(2+) -regulated photoproteins activated with CTZ-v also display red-shifted light emission, in contrast to Renilla luciferase their bioluminescence activities are very low, which makes photoproteins activated by CTZ-v unusable for calcium imaging. Here, w …
Although Ca(2+) -regulated photoproteins activated with CTZ-v also display red-shifted light emission, in contrast to Renilla lucifer …
Effective Perturbations by Small-Molecule Modulators on Voltage-Dependent Hysteresis of Transmembrane Ionic Currents.
Wu SN, Wu CL, Cho HY, Chiang CW. Wu SN, et al. Among authors: wu cl. Int J Mol Sci. 2022 Aug 21;23(16):9453. doi: 10.3390/ijms23169453. Int J Mol Sci. 2022. PMID: 36012718 Free PMC article. Review.
A variety of small molecules may influence the strength of Hys((V)) in different types of ionic currents elicited by long-lasting triangular V(ramp). Pirfenidone, an anti-fibrotic drug, decreased the magnitude of I(h)'s Hys((V)) activated by triangular V …
A variety of small molecules may influence the strength of Hys((V)) in different types of ionic currents elicited by long-lasting tri …
Structure-Function Relationship of the Voltage-Gated Calcium Channel Ca(v)1.1 Complex.
Wu J, Yan N, Yan Z. Wu J, et al. Adv Exp Med Biol. 2017;981:23-39. doi: 10.1007/978-3-319-55858-5_2. Adv Exp Med Biol. 2017. PMID: 29594856 Review.
In mammals, there are ten subtypes of Ca(v) channel, among which Ca(v)1.1 is the first Ca(v)alpha1 to be cloned. Ca(v)1.1 is specified for the excitation-contraction coupling of skeletal muscles, and has been a prototype in the structural investigation …
In mammals, there are ten subtypes of Ca(v) channel, among which Ca(v)1.1 is the first Ca(v)alpha1 to be cloned. Ca( …
Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis.
Wang S, Han Y, Liu R, Hou M, Neumann D, Zhang J, Wang F, Li Y, Zhao X, Schianchi F, Dai C, Liu L, Nabben M, Glatz JFC, Wu X, Lu X, Li X, Luiken JJFP. Wang S, et al. Among authors: wu x. Circ Res. 2024 Mar;134(5):505-525. doi: 10.1161/CIRCRESAHA.123.322910. Epub 2024 Feb 7. Circ Res. 2024. PMID: 38422177 Free PMC article.
To confirm the involvement of v-ATPase in the beneficial effects of both supplementations, mTORC1/v-ATPase inhibitors (rapamycin/bafilomycin A1) were administered. Additionally, 2 heart-specific v-ATPase-knockout mouse models (subunits V(1)G1/V( …
To confirm the involvement of v-ATPase in the beneficial effects of both supplementations, mTORC1/v-ATPase inhibitors (rapamyc …
The T-type calcium channel Ca(V)3.2 regulates insulin secretion in the pancreatic beta-cell.
Barghouth M, Ye Y, Karagiannopoulos A, Ma Y, Cowan E, Wu R, Eliasson L, Renström E, Luan C, Zhang E. Barghouth M, et al. Among authors: wu r. Cell Calcium. 2022 Dec;108:102669. doi: 10.1016/j.ceca.2022.102669. Epub 2022 Oct 31. Cell Calcium. 2022. PMID: 36347081 Free article.
Moreover, the endoplasmic reticulum (ER) Ca(2+) store depletion is also impaired in Ca(V)3.2-silenced beta-cells. The linkage between T-type (Ca(V)3.2) and L-type Ca(V) channels is further identified by the finding that the intracellular Ca(2+) signaling cond …
Moreover, the endoplasmic reticulum (ER) Ca(2+) store depletion is also impaired in Ca(V)3.2-silenced beta-cells. The linkage between …
D-mannose acts as a V-ATPase inhibitor to suppress inflammatory cytokines generation and bacterial killing in macrophage.
Zhao M, Chen N, Guo Y, Wu N, Cao B, Zhan B, Li Y, Zhou T, Zhu F, Guo C, Shi Y, Wang Q, Li Y, Zhang L. Zhao M, et al. Among authors: wu n. Mol Immunol. 2023 Oct;162:84-94. doi: 10.1016/j.molimm.2023.08.013. Epub 2023 Sep 1. Mol Immunol. 2023. PMID: 37660434
Vacuolar-type H(+)-ATPase (V-ATPase) critically controls phagosome acidification to promote pathogen digestion and clearance in macrophage. ...Therefore, identifying the unique function of the separate subunit of V-ATPase is extremely important to regulate macrophag …
Vacuolar-type H(+)-ATPase (V-ATPase) critically controls phagosome acidification to promote pathogen digestion and clearance in macro …
Dissection of the structure-function relationship of Na(v) channels.
Li Z, Wu Q, Huang G, Jin X, Li J, Pan X, Yan N. Li Z, et al. Among authors: wu q. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2322899121. doi: 10.1073/pnas.2322899121. Epub 2024 Feb 21. Proc Natl Acad Sci U S A. 2024. PMID: 38381792
To delineate the structure-function relationship of human Na(v) channels, we have performed systematic structural analysis using human Na(v)1.7 as a prototype. ...However, the variant containing these two mutations, Na(v)1.7-M2, or even in combination with tw …
To delineate the structure-function relationship of human Na(v) channels, we have performed systematic structural analysis using huma …
17,166 results
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