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Year | Number of Results |
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2021 | 1 |
2022 | 4 |
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2024 | 1 |
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Page 1
An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer.
Nat Cancer. 2022 Apr;3(4):402-417. doi: 10.1038/s43018-022-00351-8. Epub 2022 Apr 14.
Nat Cancer. 2022.
PMID: 35422503
Free PMC article.
Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.
Beyett TS, To C, Heppner DE, Rana JK, Schmoker AM, Jang J, De Clercq DJH, Gomez G, Scott DA, Gray NS, Jänne PA, Eck MJ.
Beyett TS, et al. Among authors: rana jk.
Nat Commun. 2022 May 9;13(1):2530. doi: 10.1038/s41467-022-30258-y.
Nat Commun. 2022.
PMID: 35534503
Free PMC article.
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Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
Amrhein JA, Beyett TS, Feng WW, Krämer A, Weckesser J, Schaeffner IK, Rana JK, Jänne PA, Eck MJ, Knapp S, Hanke T.
Amrhein JA, et al. Among authors: rana jk.
J Med Chem. 2022 Dec 8;65(23):15679-15697. doi: 10.1021/acs.jmedchem.2c01041. Epub 2022 Nov 16.
J Med Chem. 2022.
PMID: 36384036
Free PMC article.
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Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
Wittlinger F, Heppner DE, To C, Günther M, Shin BH, Rana JK, Schmoker AM, Beyett TS, Berger LM, Berger BT, Bauer N, Vasta JD, Corona CR, Robers MB, Knapp S, Jänne PA, Eck MJ, Laufer SA.
Wittlinger F, et al. Among authors: rana jk.
J Med Chem. 2022 Jan 27;65(2):1370-1383. doi: 10.1021/acs.jmedchem.1c00848. Epub 2021 Oct 20.
J Med Chem. 2022.
PMID: 34668706
Free PMC article.
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Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase.
Beyett TS, Rana JK, Schaeffner IK, Heppner DE, Eck MJ.
Beyett TS, et al. Among authors: rana jk.
ChemMedChem. 2024 Mar 24:e202300343. doi: 10.1002/cmdc.202300343. Online ahead of print.
ChemMedChem. 2024.
PMID: 38523074
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Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain.
Navratna V, Kumar A, Rana JK, Mosalaganti S.
Navratna V, et al. Among authors: rana jk.
bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.572875. doi: 10.1101/2023.12.21.572875.
bioRxiv. 2023.
PMID: 38187772
Free PMC article.
Preprint.
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