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A lipopeptidomimetic of transcriptional activation domains selectively disrupts Med25 PPIs.
Pattelli ON, Valdivia EM, Beyersdorf MS, Regan CS, Rivas M, Merajver SD, Cierpicki T, Mapp AK. Pattelli ON, et al. Among authors: beyersdorf ms. bioRxiv [Preprint]. 2023 Mar 25:2023.03.24.534168. doi: 10.1101/2023.03.24.534168. bioRxiv. 2023. Update in: Angew Chem Int Ed Engl. 2024 May 21;63(21):e202400781. doi: 10.1002/anie.202400781. PMID: 36993479 Free PMC article. Updated. Preprint.
Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators.
Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL 3rd, Fierke CA, Mapp AK. Henderson AR, et al. Among authors: beyersdorf ms. Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8960-8965. doi: 10.1073/pnas.1806202115. Epub 2018 Aug 20. Proc Natl Acad Sci U S A. 2018. PMID: 30127017 Free PMC article.
Assembly states of FliM and FliG within the flagellar switch complex.
Sircar R, Borbat PP, Lynch MJ, Bhatnagar J, Beyersdorf MS, Halkides CJ, Freed JH, Crane BR. Sircar R, et al. Among authors: beyersdorf ms. J Mol Biol. 2015 Feb 27;427(4):867-886. doi: 10.1016/j.jmb.2014.12.009. Epub 2014 Dec 20. J Mol Biol. 2015. PMID: 25536293 Free PMC article.