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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 2
1976 1
1978 1
1979 1
1980 4
1981 2
1982 6
1983 7
1984 7
1985 6
1986 9
1987 13
1988 12
1989 13
1990 9
1991 16
1992 20
1993 18
1994 12
1995 13
1996 19
1997 18
1998 29
1999 21
2000 26
2001 19
2002 30
2003 23
2004 29
2005 36
2006 34
2007 25
2008 30
2009 32
2010 39
2011 36
2012 37
2013 43
2014 54
2015 51
2016 47
2017 46
2018 59
2019 69
2020 83
2021 73
2022 76
2023 80
2024 43

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1,254 results

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Page 1
Identification of SARS-CoV-2 M(pro) inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2.
Higashi-Kuwata N, Tsuji K, Hayashi H, Bulut H, Kiso M, Imai M, Ogata-Aoki H, Ishii T, Kobayakawa T, Nakano K, Takamune N, Kishimoto N, Hattori SI, Das D, Uemura Y, Shimizu Y, Aoki M, Hasegawa K, Suzuki S, Nishiyama A, Saruwatari J, Shimizu Y, Sukenaga Y, Takamatsu Y, Tsuchiya K, Maeda K, Yoshimura K, Iida S, Ozono S, Suzuki T, Okamura T, Misumi S, Kawaoka Y, Tamamura H, Mitsuya H. Higashi-Kuwata N, et al. Among authors: yoshimura k. Nat Commun. 2023 Feb 25;14(1):1076. doi: 10.1038/s41467-023-36729-0. Nat Commun. 2023. PMID: 36841831 Free PMC article.
Here, we identify two orally available 4-fluoro-benzothiazole-containing small molecules, TKB245 and TKB248, which specifically inhibit the enzymatic activity of main protease (M(pro)) of SARS-CoV-2 and significantly more potently block the infectivity and replication of v …
Here, we identify two orally available 4-fluoro-benzothiazole-containing small molecules, TKB245 and TKB248, which specifically inhibit the …
Clinical Characteristics and Outcomes Among Travelers With Severe Dengue : A GeoSentinel Analysis.
Huits R, Angelo KM, Amatya B, Barkati S, Barnett ED, Bottieau E, Emetulu H, Epelboin L, Eperon G, Medebb L, Gobbi F, Grobusch MP, Itani O, Jordan S, Kelly P, Leder K, Díaz-Menéndez M, Okumura N, Rizwan A, Rothe C, Saio M, Waggoner J, Yoshimura Y, Libman M, Hamer DH, Schwartz E. Huits R, et al. Among authors: yoshimura y. Ann Intern Med. 2023 Jul;176(7):940-948. doi: 10.7326/M23-0721. Epub 2023 Jun 20. Ann Intern Med. 2023. PMID: 37335991 Free PMC article.
Micelle Formation of Monoammonium Glycyrrhizinate.
Matsuoka K, Arima M, Goto Y, Yada S, Yoshimura T. Matsuoka K, et al. Among authors: yoshimura t. J Oleo Sci. 2021;70(7):911-918. doi: 10.5650/jos.ess21046. J Oleo Sci. 2021. PMID: 34193668 Free article.
The critical micelle concentration (CMC) and surface tension at the CMC (gamma(CMC)) of monoammonium glycyrrhizinate were determined by the surface tension method to be 1.5 mmol L(-1) and 50 mN m(-1) in pH 5 buffer and 3.7 mmol L(-1) and 51 mN m(-1) in pH 6 buffer, …
The critical micelle concentration (CMC) and surface tension at the CMC (gamma(CMC)) of monoammonium glycyrrhizinate were determined by the …
Non-amplification nucleic acid detection with thio-NAD cycling.
Yamura S, Kawada N, Yamakado S, Kyosei Y, Watabe S, Yoshimura T, Murase Y, Mitarai S, Ito E. Yamura S, et al. Among authors: yoshimura t. J Microbiol Methods. 2023 Jan;204:106647. doi: 10.1016/j.mimet.2022.106647. Epub 2022 Dec 7. J Microbiol Methods. 2023. PMID: 36496031
The single-stranded DNA, double-stranded DNA, plasmid DNA for the mpt64 gene, and whole genome of M. tuberculosis var. BCG were detected at the level of 10(5)-10(6) copies/assay, whereas the non-tuberculosis mycobacteria (e.g., M. avium, M. intracellulare, …
The single-stranded DNA, double-stranded DNA, plasmid DNA for the mpt64 gene, and whole genome of M. tuberculosis var. BCG were detec …
Potentiation of Muscarinic M(3) Receptor Activation through a New Allosteric Site with a Novel Positive Allosteric Modulator ASP8302.
Okimoto R, Ino K, Ishizu K, Takamatsu H, Sakamoto K, Yuyama H, Fuji H, Someya A, Ohtake A, Ishigami T, Masuda N, Takeda M, Kajioka S, Yoshimura N. Okimoto R, et al. Among authors: yoshimura n. J Pharmacol Exp Ther. 2021 Oct;379(1):64-73. doi: 10.1124/jpet.121.000709. Epub 2021 Jul 8. J Pharmacol Exp Ther. 2021. PMID: 34244231
Muscarinic M(3) (M(3)) receptors mediate a wide range of acetylcholine (ACh)-induced functions, including visceral smooth-muscle contraction and glandular secretion. ...Our findings suggest not only a novel allosteric site of M(3) receptors but also the poten …
Muscarinic M(3) (M(3)) receptors mediate a wide range of acetylcholine (ACh)-induced functions, including visceral smooth-musc …
Endovascular Therapy in Acute Ischemic Stroke: Challenges and Transition From Trials to Bedside.
Goyal M, Yu AY, Menon BK, Dippel DW, Hacke W, Davis SM, Fisher M, Yavagal DR, Turjman F, Ross J, Yoshimura S, Miao Z, Bhatia R, Almekhlafi M, Murayama Y, Sohn SI, Saver JL, Demchuk AM, Hill MD. Goyal M, et al. Among authors: yoshimura s. Stroke. 2016 Feb;47(2):548-53. doi: 10.1161/STROKEAHA.115.011426. Epub 2016 Jan 7. Stroke. 2016. PMID: 26742796 Review. No abstract available.
Paraneoplastic Cerebellar Degeneration With P/Q-VGCC vs Yo Autoantibodies.
Winklehner M, Bauer J, Endmayr V, Schwaiger C, Ricken G, Motomura M, Yoshimura S, Shintaku H, Ishikawa K, Tsuura Y, Iizuka T, Yokota T, Irioka T, Höftberger R. Winklehner M, et al. Among authors: yoshimura s. Neurol Neuroimmunol Neuroinflamm. 2022 Jul 7;9(4):e200006. doi: 10.1212/NXI.0000000000200006. Print 2022 Jul. Neurol Neuroimmunol Neuroinflamm. 2022. PMID: 36070310 Free PMC article.
Renal dysfunction, malignant neoplasms, atherosclerotic cardiovascular diseases, and sarcopenia as key outcomes observed in a three-year follow-up study using the Werner Syndrome Registry.
Maeda Y, Koshizaka M, Shoji M, Kaneko H, Kato H, Maezawa Y, Kawashima J, Yoshinaga K, Ishikawa M, Sekiguchi A, Motegi SI, Nakagami H, Yamada Y, Tsukamoto S, Taniguchi A, Sugimoto K, Takami Y, Shoda Y, Hashimoto K, Yoshimura T, Kogure A, Suzuki D, Okubo N, Yoshida T, Watanabe K, Kuzuya M, Takemoto M, Oshima J, Yokote K. Maeda Y, et al. Among authors: yoshimura t. Aging (Albany NY). 2023 May 1;15(9):3273-3294. doi: 10.18632/aging.204681. Epub 2023 May 1. Aging (Albany NY). 2023. PMID: 37130431 Free PMC article.
Regarding renal function, the mean estimated glomerular filtration rate calculated from serum creatinine (eGFRcre) and eGFRcys, which were calculated from cystatin C in the first year, were 98.3 and 83.2 mL/min/1.73 m(2), respectively, and differed depending on the index u …
Regarding renal function, the mean estimated glomerular filtration rate calculated from serum creatinine (eGFRcre) and eGFRcys, which were c …
Sex Differences in Outcomes of Late-Window Endovascular Stroke Therapy.
Abdalkader M, Ning S, Qureshi MM, Haussen DC, Strbian D, Nagel S, Demeestere J, Puetz V, Mohammaden MH, Olive Gadea M, Winzer S, Yamagami H, Tanaka K, Marto JP, Tomppo L, Henon H, Sheth SA, Ortega-Gutierrez S, Martinez-Majander N, Caparros F, Lemmens R, Dusart A, Bellante F, Zaidi SF, Siegler JE, Nannoni S, Kaesmacher J, Dobrocky T, Farooqui M, Salazar-Marioni S, Virtanen P, Vandewalle L, Wouters A, Jesser J, Ventura R, Castonguay AC, Uchida K, Puri AS, Masoud HE, Klein P, Mansoor Z, Bui J, Kang M, Mujanovic A, Rizzo F, Kokkonen T, Ramos JN, Strambo D, Michel P, Möhlenbruch MA, Lin E, Kaiser DPO, Yoshimura S, Sakai N, Cordonnier C, Ringleb PA, Roy D, Zaidat OO, Fischer U, Ribo M, Raymond J, Nogueira RG, Nguyen TN. Abdalkader M, et al. Among authors: yoshimura s. Stroke. 2024 Feb;55(2):278-287. doi: 10.1161/STROKEAHA.123.045015. Epub 2024 Jan 22. Stroke. 2024. PMID: 38252759
Effects of sleep restriction on food intake and appetite under free-living conditions: A randomized crossover trial.
Tajiri E, Yoshimura E, Tobina T, Yamashita T, Kume K, Hatamoto Y, Shimoda S. Tajiri E, et al. Among authors: yoshimura e. Appetite. 2023 Oct 1;189:106998. doi: 10.1016/j.appet.2023.106998. Epub 2023 Aug 9. Appetite. 2023. PMID: 37562755 Clinical Trial.
Fasting blood samples were collected at 8:00 a.m. on day 4. Dietary intake during the ad libitum breakfast was assessed on day 4. The participants were 13 women and 11 men (mean age, 21.4 1.0 years; mean body mass index, 19.8 1.7 kg/m(2)). The areas under the curve …
Fasting blood samples were collected at 8:00 a.m. on day 4. Dietary intake during the ad libitum breakfast was assessed on day 4. The …
1,254 results