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Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models.
Kuta R, Larochelle N, Fernandez M, Pal A, Minotti S, Tibshirani M, St Louis K, Gentil BJ, Nalbantoglu JN, Hermann A, Durham HD. Kuta R, et al. Among authors: nalbantoglu jn. Cell Stress Chaperones. 2020 Jan;25(1):173-191. doi: 10.1007/s12192-019-01064-1. Epub 2020 Jan 3. Cell Stress Chaperones. 2020. PMID: 31900865 Free PMC article.
Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS.
Fernández Comaduran M, Minotti S, Jacob-Tomas S, Rizwan J, Larochelle N, Robitaille R, Sephton CF, Vera M, Nalbantoglu JN, Durham HD. Fernández Comaduran M, et al. Among authors: nalbantoglu jn. Cell Stress Chaperones. 2024 Apr 1;29(3):359-380. doi: 10.1016/j.cstres.2024.03.010. Online ahead of print. Cell Stress Chaperones. 2024. PMID: 38570009 Free PMC article.