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Precise genomic deletions using paired prime editing.
Choi J, Chen W, Suiter CC, Lee C, Chardon FM, Yang W, Leith A, Daza RM, Martin B, Shendure J. Choi J, et al. Among authors: chardon fm. Nat Biotechnol. 2022 Feb;40(2):218-226. doi: 10.1038/s41587-021-01025-z. Epub 2021 Oct 14. Nat Biotechnol. 2022. PMID: 34650269 Free PMC article.
Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements.
Chardon FM, McDiarmid TA, Page NF, Daza RM, Martin B, Domcke S, Regalado SG, Lalanne JB, Calderon D, Li X, Starita LM, Sanders SJ, Ahituv N, Shendure J. Chardon FM, et al. bioRxiv [Preprint]. 2024 Apr 30:2023.03.28.534017. doi: 10.1101/2023.03.28.534017. bioRxiv. 2024. PMID: 37034704 Free PMC article. Preprint.
A time-resolved, multi-symbol molecular recorder via sequential genome editing.
Choi J, Chen W, Minkina A, Chardon FM, Suiter CC, Regalado SG, Domcke S, Hamazaki N, Lee C, Martin B, Daza RM, Shendure J. Choi J, et al. Among authors: chardon fm. Nature. 2022 Aug;608(7921):98-107. doi: 10.1038/s41586-022-04922-8. Epub 2022 Jul 6. Nature. 2022. PMID: 35794474 Free PMC article.
Chromatin context-dependent regulation and epigenetic manipulation of prime editing.
Li X, Chen W, Martin BK, Calderon D, Lee C, Choi J, Chardon FM, McDiarmid TA, Daza RM, Kim H, Lalanne JB, Nathans JF, Lee DS, Shendure J. Li X, et al. Among authors: chardon fm. Cell. 2024 May 9;187(10):2411-2427.e25. doi: 10.1016/j.cell.2024.03.020. Epub 2024 Apr 11. Cell. 2024. PMID: 38608704 Free article.
Chromatin context-dependent regulation and epigenetic manipulation of prime editing.
Li X, Chen W, Martin BK, Calderon D, Lee C, Choi J, Chardon FM, McDiarmid T, Kim H, Lalanne JB, Nathans JF, Shendure J. Li X, et al. Among authors: chardon fm. bioRxiv [Preprint]. 2023 Apr 12:2023.04.12.536587. doi: 10.1101/2023.04.12.536587. bioRxiv. 2023. Update in: Cell. 2024 May 9;187(10):2411-2427.e25. doi: 10.1016/j.cell.2024.03.020. PMID: 37090511 Free PMC article. Updated. Preprint.