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Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity.
Rodriguez-Zabala M, Ramakrishnan R, Reinbach K, Ghosh S, Oburoglu L, Falqués-Costa A, Bellamkonda K, Ehinger M, Peña-Martínez P, Puente-Moncada N, Lilljebjörn H, Cammenga J, Pronk CJ, Lazarevic V, Fioretos T, Hagström-Andersson AK, Woods NB, Järås M. Rodriguez-Zabala M, et al. Among authors: hagstrom andersson ak. Blood Adv. 2023 Sep 26;7(18):5382-5395. doi: 10.1182/bloodadvances.2023009967. Blood Adv. 2023. PMID: 37505194 Free PMC article.
Targeting GLUT1 in acute myeloid leukemia to overcome cytarabine resistance.
Åbacka H, Hansen JS, Huang P, Venskutonytė R, Hyrenius-Wittsten A, Poli G, Tuccinardi T, Granchi C, Minutolo F, Hagström-Andersson AK, Lindkvist-Petersson K. Åbacka H, et al. Among authors: hagstrom andersson ak. Haematologica. 2021 Apr 1;106(4):1163-1166. doi: 10.3324/haematol.2020.246843. Haematologica. 2021. PMID: 32554563 Free PMC article. No abstract available.
Duplex Sequencing Uncovers Recurrent Low-frequency Cancer-associated Mutations in Infant and Childhood KMT2A-rearranged Acute Leukemia.
Pilheden M, Ahlgren L, Hyrenius-Wittsten A, Gonzalez-Pena V, Sturesson H, Hansen Marquart HV, Lausen B, Castor A, Pronk CJ, Barbany G, Pokrovskaja Tamm K, Fogelstrand L, Lohi O, Norén-Nyström U, Asklin J, Chen Y, Song G, Walsh M, Ma J, Zhang J, Saal LH, Gawad C, Hagström-Andersson AK. Pilheden M, et al. Among authors: hagstrom andersson ak. Hemasphere. 2022 Sep 30;6(10):e785. doi: 10.1097/HS9.0000000000000785. eCollection 2022 Oct. Hemasphere. 2022. PMID: 36204688 Free PMC article.
FLT3N676K drives acute myeloid leukemia in a xenograft model of KMT2A-MLLT3 leukemogenesis.
Hyrenius-Wittsten A, Pilheden M, Falqués-Costa A, Eriksson M, Sturesson H, Schneider P, Wander P, Garcia-Ruiz C, Liu J, Ågerstam H, Hultquist A, Lilljebjörn H, Stam RW, Järås M, Hagström-Andersson AK. Hyrenius-Wittsten A, et al. Among authors: hagstrom andersson ak. Leukemia. 2019 Sep;33(9):2310-2314. doi: 10.1038/s41375-019-0465-1. Epub 2019 Apr 5. Leukemia. 2019. PMID: 30953031 Free PMC article. No abstract available.
De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.
Hyrenius-Wittsten A, Pilheden M, Sturesson H, Hansson J, Walsh MP, Song G, Kazi JU, Liu J, Ramakrishan R, Garcia-Ruiz C, Nance S, Gupta P, Zhang J, Rönnstrand L, Hultquist A, Downing JR, Lindkvist-Petersson K, Paulsson K, Järås M, Gruber TA, Ma J, Hagström-Andersson AK. Hyrenius-Wittsten A, et al. Among authors: hagstrom andersson ak. Nat Commun. 2018 May 2;9(1):1770. doi: 10.1038/s41467-018-04180-1. Nat Commun. 2018. PMID: 29720585 Free PMC article.
Sequential drug treatment targeting cell cycle and cell fate regulatory programs blocks non-genetic cancer evolution in acute lymphoblastic leukemia.
Malyukova A, Lahnalampi M, Falqués-Costa T, Pölönen P, Sipola M, Mehtonen J, Teppo S, Akopyan K, Viiliainen J, Lohi O, Hagström-Andersson AK, Heinäniemi M, Sangfelt O. Malyukova A, et al. Among authors: hagstrom andersson ak. Genome Biol. 2024 May 31;25(1):143. doi: 10.1186/s13059-024-03260-4. Genome Biol. 2024. PMID: 38822412