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2017 1
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2021 6
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Page 1
Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis.
Machado-Neto JA, Fenerich BA, Rodrigues Alves APN, Fernandes JC, Scopim-Ribeiro R, Coelho-Silva JL, Traina F. Machado-Neto JA, et al. Among authors: coelho silva jl. Clinics (Sao Paulo). 2018 Oct 11;73(suppl 1):e566s. doi: 10.6061/clinics/2018/e566s. Clinics (Sao Paulo). 2018. PMID: 30328953 Free PMC article. Review.
Phenformin increases early hematopoietic progenitors in the Jak2V617F murine model.
Alves-Silva AB, Fenerich BA, Fonseca NP, Fernandes JC, Coelho-Silva JL, Pereira-Martins DA, Bianco TM, Scheucher PS, Rego EM, Chahud F, Machado-Neto JA, Figueiredo-Pontes LL, Traina F. Alves-Silva AB, et al. Among authors: coelho silva jl. Invest New Drugs. 2022 Jun;40(3):576-585. doi: 10.1007/s10637-022-01212-y. Epub 2022 Jan 11. Invest New Drugs. 2022. PMID: 35015172
Autophagy inhibition potentiates ruxolitinib-induced apoptosis in JAK2V617F cells.
Machado-Neto JA, Coelho-Silva JL, Santos FPS, Scheucher PS, Campregher PV, Hamerschlak N, Rego EM, Traina F. Machado-Neto JA, et al. Among authors: coelho silva jl. Invest New Drugs. 2020 Jun;38(3):733-745. doi: 10.1007/s10637-019-00812-5. Epub 2019 Jul 8. Invest New Drugs. 2020. PMID: 31286322
STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells.
Vicari HP, Coelho-Silva JL, Pereira-Martins DA, Lucena-Araujo AR, Lima K, Lipreri da Silva JC, Scheucher PS, Koury LC, de Melo RA, Bittencourt R, Pagnano K, Nunes E, Fagundes EM, Kerbauy F, de Figueiredo-Pontes LL, Costa-Lotufo LV, Rego EM, Traina F, Machado-Neto JA. Vicari HP, et al. Among authors: coelho silva jl. Invest New Drugs. 2022 Apr;40(2):438-452. doi: 10.1007/s10637-021-01197-0. Epub 2021 Nov 27. Invest New Drugs. 2022. PMID: 34837603
The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy.
Lima K, Pereira-Martins DA, de Miranda LBL, Coelho-Silva JL, Leandro GDS, Weinhäuser I, Cavaglieri RC, Leal AM, da Silva WF, Lange APAL, Velloso EDRP, Griessinger E, Hilberink JR, Ammatuna E, Huls G, Schuringa JJ, Rego EM, Machado-Neto JA. Lima K, et al. Among authors: coelho silva jl. Blood Cancer J. 2022 Nov 9;12(11):151. doi: 10.1038/s41408-022-00747-w. Blood Cancer J. 2022. PMID: 36347832 Free PMC article.
NT157, an IGF1R-IRS1/2 inhibitor, exhibits antineoplastic effects in pre-clinical models of chronic myeloid leukemia.
Scopim-Ribeiro R, Machado-Neto JA, Eide CA, Coelho-Silva JL, Fenerich BA, Fernandes JC, Scheucher PS, Savage Stevens SL, de Melo Campos P, Olalla Saad ST, de Carvalho Palma L, de Figueiredo-Pontes LL, Simões BP, Rego EM, Tognon CE, Druker BJ, Traina F. Scopim-Ribeiro R, et al. Among authors: coelho silva jl. Invest New Drugs. 2021 Jun;39(3):736-746. doi: 10.1007/s10637-020-01028-8. Epub 2021 Jan 6. Invest New Drugs. 2021. PMID: 33403501
MLL5 improves ATRA driven differentiation and promotes xenotransplant engraftment in acute promyelocytic leukemia model.
Pereira-Martins DA, Weinhäuser I, Coelho-Silva JL, França-Neto PL, Almeida LY, Bianco TM, Silva CL, França RF, Traina F, Rego EM, Schuringa JJ, Lucena-Araujo AR. Pereira-Martins DA, et al. Among authors: coelho silva jl. Cell Death Dis. 2021 Apr 6;12(4):371. doi: 10.1038/s41419-021-03604-z. Cell Death Dis. 2021. PMID: 33824267 Free PMC article.
Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms.
Machado-Neto JA, Fenerich BA, Scopim-Ribeiro R, Eide CA, Coelho-Silva JL, Dechandt CRP, Fernandes JC, Rodrigues Alves APN, Scheucher PS, Simões BP, Alberici LC, de Figueiredo Pontes LL, Tognon CE, Druker BJ, Rego EM, Traina F. Machado-Neto JA, et al. Among authors: coelho silva jl. Cell Death Dis. 2018 Feb 22;9(3):311. doi: 10.1038/s41419-017-0256-4. Cell Death Dis. 2018. PMID: 29472557 Free PMC article.
20 results