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Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.
Patil H, Yoon D, Bhowmick R, Cai Y, Cho KI, Ferreira PA. Patil H, et al. Small GTPases. 2019 Mar;10(2):146-161. doi: 10.1080/21541248.2017.1356432. Epub 2017 Sep 29. Small GTPases. 2019. PMID: 28877029 Free PMC article.
Proteostatic remodeling of small heat shock chaperones - crystallins by Ran-binding protein 2 and the peptidyl-prolyl cis-trans isomerase and chaperone activities of its cyclophilin domain.
Patil H, Cho KI, Ferreira PA. Patil H, et al. bioRxiv [Preprint]. 2024 Jan 30:2024.01.26.577462. doi: 10.1101/2024.01.26.577462. bioRxiv. 2024. Update in: ACS Chem Neurosci. 2024 May 15;15(10):1967-1989. doi: 10.1021/acschemneuro.3c00792. PMID: 38352504 Free PMC article. Updated. Preprint.
The nucleosome-binding protein HMGN2 modulates global genome repair.
Subramanian M, Gonzalez RW, Patil H, Ueda T, Lim JH, Kraemer KH, Bustin M, Bergel M. Subramanian M, et al. Among authors: patil h. FEBS J. 2009 Nov;276(22):6646-57. doi: 10.1111/j.1742-4658.2009.07375.x. Epub 2009 Oct 16. FEBS J. 2009. PMID: 19843163 Free PMC article.
Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.
Patil H, Saha A, Senda E, Cho KI, Haque M, Yu M, Qiu S, Yoon D, Hao Y, Peachey NS, Ferreira PA. Patil H, et al. J Biol Chem. 2014 Oct 24;289(43):29767-89. doi: 10.1074/jbc.M114.586834. Epub 2014 Sep 3. J Biol Chem. 2014. PMID: 25187515 Free PMC article.