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Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model.
Prabakaran AD, McFarland K, Miz K, Durumutla HB, Piczer K, El Abdellaoui Soussi F, Latimer H, Werbrich C, Chung HJ, Blair NS, Millay DP, Morris AJ, Prideaux B, Finck BN, Quattrocelli M. Prabakaran AD, et al. Among authors: latimer h. J Clin Invest. 2024 May 3;134(11):e177427. doi: 10.1172/JCI177427. J Clin Invest. 2024. PMID: 38702076 Free PMC article.
Glucocorticoid intermittence coordinates rescue of energy and mass in aging-related sarcopenia through the myocyte-autonomous PGC1alpha-Lipin1 transactivation.
Prabakaran AD, McFarland K, Miz K, Durumutla HB, Piczer K, El Abdellaoui Soussi F, Latimer H, Werbrich C, Blair NS, Millay DP, Prideaux B, Finck BN, Quattrocelli M. Prabakaran AD, et al. Among authors: latimer h. bioRxiv [Preprint]. 2023 Oct 19:2023.10.16.562573. doi: 10.1101/2023.10.16.562573. bioRxiv. 2023. PMID: 37905062 Free PMC article. Preprint.
Glucocorticoid chrono-pharmacology unveils novel targets for the cardiomyocyte-specific GR-KLF15 axis in cardiac glucose metabolism.
Durumutla HB, Prabakaran AD, Soussi FEA, Akinborewa O, Latimer H, McFarland K, Piczer K, Werbrich C, Jain MK, Haldar SM, Quattrocelli M. Durumutla HB, et al. Among authors: latimer h. bioRxiv [Preprint]. 2024 Sep 11:2023.12.18.572210. doi: 10.1101/2023.12.18.572210. bioRxiv. 2024. PMID: 38187555 Free PMC article. Preprint.
The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel pro-metabolic targets of the glucocorticoid receptor in muscle.
Prabakaran AD, Chung HJ, McFarland K, Govindarajan T, El Abdellaoui Soussi F, Durumutla HB, Villa C, Piczer K, Latimer H, Werbrich C, Akinborewa O, Horning R, Quattrocelli M. Prabakaran AD, et al. Among authors: latimer h. bioRxiv [Preprint]. 2024 Mar 31:2024.03.28.586997. doi: 10.1101/2024.03.28.586997. bioRxiv. 2024. PMID: 38585940 Free PMC article. Preprint.
Glucocorticoid chrono-pharmacology promotes glucose metabolism in heart through a cardiomyocyte-autonomous transactivation program.
Durumutla HB, Prabakaran A, El Abdellaoui Soussi F, Akinborewa O, Latimer H, McFarland K, Piczer K, Werbrich C, Jain MK, Haldar SM, Quattrocelli M. Durumutla HB, et al. Among authors: latimer h. JCI Insight. 2024 Oct 8:e182599. doi: 10.1172/jci.insight.182599. Online ahead of print. JCI Insight. 2024. PMID: 39378111 Free article.