Mitch CH - Search Results

1

Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs.

Sauerberg P, Olesen PH, Sheardown MJ, Suzdak PD, Shannon HE, Bymaster FP, Calligaro DO, Mitch CH, Ward JS, Swedberg MD. Sauerberg P, et al. Among authors: mitch ch. Life Sci. 1995;56(11-12):807-14. doi: 10.1016/0024-3205(95)00014-w. Life Sci. 1995. PMID: 10188779

2

Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines.

Sauerberg P, Olesen PH, Nielsen S, Treppendahl S, Sheardown MJ, Honoré T, Mitch CH, Ward JS, Pike AJ, Bymaster FP, et al. Sauerberg P, et al. Among authors: mitch ch. J Med Chem. 1992 Jun 12;35(12):2274-83. doi: 10.1021/jm00090a019. J Med Chem. 1992. PMID: 1613751

3

The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from Chinese hamster ovary-m1 cells.

Eckols K, Bymaster FP, Mitch CH, Shannon HE, Ward JS, DeLapp NW. Eckols K, et al. Among authors: mitch ch. Life Sci. 1995;57(12):1183-90. doi: 10.1016/0024-3205(95)02064-p. Life Sci. 1995. PMID: 7674807

4

In vivo pharmacology of butylthio[2.2.2] (LY297802 / NNC11-1053), an orally acting antinociceptive muscarinic agonist.

Shannon HE, Womer DE, Bymaster FP, Calligaro DO, DeLapp NC, Mitch CH, Ward JS, Whitesitt CA, Swedberg MD, Sheardown MJ, Fink-Jensen A, Olesen PH, Rimvall K, Sauerberg P. Shannon HE, et al. Among authors: mitch ch. Life Sci. 1997;60(13-14):969-76. doi: 10.1016/s0024-3205(97)00036-2. Life Sci. 1997. PMID: 9121363 Review.

5

M1 receptor agonist activity is not a requirement for muscarinic antinociception.

Sheardown MJ, Shannon HE, Swedberg MD, Suzdak PD, Bymaster FP, Olesen PH, Mitch CH, Ward JS, Sauerberg P. Sheardown MJ, et al. Among authors: mitch ch. J Pharmacol Exp Ther. 1997 May;281(2):868-75. J Pharmacol Exp Ther. 1997. PMID: 9152396

6

Butylthio[2.2.2] (NNC 11-1053/LY297802): an orally active muscarinic agonist analgesic.

Swedberg MD, Sheardown MJ, Sauerberg P, Olesen PH, Suzdak PD, Hansen KT, Bymaster FP, Ward JS, Mitch CH, Calligaro DO, Delapp NW, Shannon HE. Swedberg MD, et al. Among authors: mitch ch. J Pharmacol Exp Ther. 1997 May;281(2):876-83. J Pharmacol Exp Ther. 1997. PMID: 9152397

7

Potential role of muscarinic receptors in schizophrenia.

Bymaster FP, Shannon HE, Rasmussen K, DeLapp NW, Ward JS, Calligaro DO, Mitch CH, Whitesitt C, Ludvigsen TS, Sheardown M, Swedberg M, Rasmussen T, Olesen PH, Jeppesen L, Sauerberg P, Fink-Jensen A. Bymaster FP, et al. Among authors: mitch ch. Life Sci. 1999;64(6-7):527-34. doi: 10.1016/s0024-3205(98)00597-9. Life Sci. 1999. PMID: 10069519

8

Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore.

Ward JS, Merritt L, Klimkowski VJ, Lamb ML, Mitch CH, Bymaster FP, Sawyer B, Shannon HE, Olesen PH, Honoré T, et al. Ward JS, et al. Among authors: mitch ch. J Med Chem. 1992 Oct 30;35(22):4011-9. doi: 10.1021/jm00100a005. J Med Chem. 1992. PMID: 1433209

9

Functionally selective M1 muscarinic agonists. 3. Side chains and azacycles contributing to functional muscarinic selectivity among pyrazinylazacycles.

Ward JS, Merritt L, Calligaro DO, Bymaster FP, Shannon HE, Sawyer BD, Mitch CH, Deeter JB, Peters SC, Sheardown MJ, Olesen PH, Swedberg MD, Sauerberg P. Ward JS, et al. Among authors: mitch ch. J Med Chem. 1995 Sep 1;38(18):3469-81. doi: 10.1021/jm00018a007. J Med Chem. 1995. PMID: 7658434

10

Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors.

Shannon HE, Bymaster FP, Calligaro DO, Greenwood B, Mitch CH, Sawyer BD, Ward JS, Wong DT, Olesen PH, Sheardown MJ, Swedberg MD, Suzdak PD, Sauerberg P. Shannon HE, et al. Among authors: mitch ch. J Pharmacol Exp Ther. 1994 Apr;269(1):271-81. J Pharmacol Exp Ther. 1994. PMID: 7909557

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