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Page 1
Discovery of a small molecule insulin mimetic with antidiabetic activity in mice.
Zhang B, Salituro G, Szalkowski D, Li Z, Zhang Y, Royo I, Vilella D, Díez MT, Pelaez F, Ruby C, Kendall RL, Mao X, Griffin P, Calaycay J, Zierath JR, Heck JV, Smith RG, Moller DE. Zhang B, et al. Among authors: salituro g. Science. 1999 May 7;284(5416):974-7. doi: 10.1126/science.284.5416.974. Science. 1999. PMID: 10320380
Activation of insulin signal transduction pathway and anti-diabetic activity of small molecule insulin receptor activators.
Qureshi SA, Ding V, Li Z, Szalkowski D, Biazzo-Ashnault DE, Xie D, Saperstein R, Brady E, Huskey S, Shen X, Liu K, Xu L, Salituro GM, Heck JV, Moller DE, Jones AB, Zhang BB. Qureshi SA, et al. Among authors: salituro gm. J Biol Chem. 2000 Nov 24;275(47):36590-5. doi: 10.1074/jbc.M006287200. J Biol Chem. 2000. PMID: 10967116 Free article.
We recently described the identification of a non-peptidyl fungal metabolite (l-783,281, compound 1), which induced activation of human insulin receptor (IR) tyrosine kinase and mediated insulin-like effects in cells, as well as decreased blood glucose levels in murine models of …
We recently described the identification of a non-peptidyl fungal metabolite (l-783,281, compound 1), which induced activation of human insu …
The basal SAR of a novel insulin receptor activator.
Wood HB Jr, Black R, Salituro G, Szalkowski D, Li Z, Zhang Y, Moller DE, Zhang B, Jones AB. Wood HB Jr, et al. Among authors: salituro g. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1189-92. doi: 10.1016/s0960-894x(00)00206-7. Bioorg Med Chem Lett. 2000. PMID: 10866378
Discovery of N-aryl-2-acylindole human glucagon receptor antagonists.
Sinz C, Bittner A, Brady E, Candelore M, Dallas-Yang Q, Ding V, Jiang G, Lin Z, Qureshi S, Salituro G, Saperstein R, Shang J, Szalkowski D, Tota L, Vincent S, Wright M, Xu S, Yang X, Zhang B, Tata J, Kim R, Parmee ER. Sinz C, et al. Among authors: salituro g. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7124-30. doi: 10.1016/j.bmcl.2011.09.105. Epub 2011 Oct 5. Bioorg Med Chem Lett. 2011. PMID: 22030028
Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists.
Sinz C, Chang J, Lins AR, Brady E, Candelore M, Dallas-Yang Q, Ding V, Jiang G, Lin Z, Mock S, Qureshi S, Salituro G, Saperstein R, Shang J, Szalkowski D, Tota L, Vincent S, Wright M, Xu S, Yang X, Zhang B, Tata J, Kim R, Parmee E. Sinz C, et al. Among authors: salituro g. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7131-6. doi: 10.1016/j.bmcl.2011.09.085. Epub 2011 Sep 29. Bioorg Med Chem Lett. 2011. PMID: 22001094
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
Singh SB, Jayasuriya H, Salituro GM, Zink DL, Shafiee A, Heimbuch B, Silverman KC, Lingham RB, Genilloud O, Teran A, Vilella D, Felock P, Hazuda D. Singh SB, et al. Among authors: salituro gm. J Nat Prod. 2001 Jul;64(7):874-82. doi: 10.1021/np000632z. J Nat Prod. 2001. PMID: 11473415
Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.
Wu M, Singh SB, Wang J, Chung CC, Salituro G, Karanam BV, Lee SH, Powles M, Ellsworth KP, Lassman ME, Miller C, Myers RW, Tota MR, Zhang BB, Li C. Wu M, et al. Among authors: salituro g. Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5378-83. doi: 10.1073/pnas.1002588108. Epub 2011 Mar 9. Proc Natl Acad Sci U S A. 2011. PMID: 21389266 Free PMC article.
Quinoxapeptins: novel chromodepsipeptide inhibitors of HIV-1 and HIV-2 reverse transcriptase. I. The producing organism and biological activity.
Lingham RB, Hsu AH, O'Brien JA, Sigmund JM, Sanchez M, Gagliardi MM, Heimbuch BK, Genilloud O, Martin I, Diez MT, Hirsch CF, Zink DL, Liesch JM, Koch GE, Gartner SE, Garrity GM, Tsou NN, Salituro GM. Lingham RB, et al. Among authors: salituro gm. J Antibiot (Tokyo). 1996 Mar;49(3):253-9. doi: 10.7164/antibiotics.49.253. J Antibiot (Tokyo). 1996. PMID: 8626240 Free article.
56 results