The COX-2 inhibitor nimesulide suppresses superoxide and 8-hydroxy-deoxyguanosine formation, and stimulates apoptosis in mucosa during early colonic inflammation in rats.
Tardieu D, Jaeg JP, Deloly A, Corpet DE, Cadet J, Petit CR.
Tardieu D, et al. Among authors: cadet j.
Carcinogenesis. 2000 May;21(5):973-6. doi: 10.1093/carcin/21.5.973.
Carcinogenesis. 2000.
PMID: 10783320
As we have shown previously [Tardieu,D., Jaeg,J.P., Cadet,J., Embvani,E., Corpet,D.E. and Petit,C. (1998) Cancer Lett, 134, 1-5], a 48-h treatment of 6% dextran sodium sulphate (DSS) in drinking water led to a reproducible 2-fold increase of the mutagenic oxi …
As we have shown previously [Tardieu,D., Jaeg,J.P., Cadet,J., Embvani,E., Corpet,D.E. and Petit,C. (1998) Cancer Lett, …