Papoulis AT - Search Results

1

Structure-based design of selective inhibitors of dihydrofolate reductase: synthesis and antiparasitic activity of 2, 4-diaminopteridine analogues with a bridged diarylamine side chain.

Rosowsky A, Cody V, Galitsky N, Fu H, Papoulis AT, Queener SF. Rosowsky A, et al. Among authors: papoulis at. J Med Chem. 1999 Nov 18;42(23):4853-60. doi: 10.1021/jm990331q. J Med Chem. 1999. PMID: 10579848

2

2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.

Rosowsky A, Papoulis AT, Queener SF. Rosowsky A, et al. Among authors: papoulis at. J Med Chem. 1997 Oct 24;40(22):3694-9. doi: 10.1021/jm970399a. J Med Chem. 1997. PMID: 9357537

3

2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine analogues of trimethoprim as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.

Rosowsky A, Papoulis AT, Queener SF. Rosowsky A, et al. Among authors: papoulis at. J Med Chem. 1998 Mar 12;41(6):913-8. doi: 10.1021/jm970614n. J Med Chem. 1998. PMID: 9526565

4

Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.

Rosowsky A, Papoulis AT, Forsch RA, Queener SF. Rosowsky A, et al. Among authors: papoulis at. J Med Chem. 1999 Mar 25;42(6):1007-17. doi: 10.1021/jm980572i. J Med Chem. 1999. PMID: 10090784

5

Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.

Good AC, Liu J, Hirth B, Asmussen G, Xiang Y, Biemann HP, Bishop KA, Fremgen T, Fitzgerald M, Gladysheva T, Jain A, Jancsics K, Metz M, Papoulis A, Skerlj R, Stepp JD, Wei RR. Good AC, et al. J Med Chem. 2012 Mar 22;55(6):2641-8. doi: 10.1021/jm2014698. Epub 2012 Mar 5. J Med Chem. 2012. PMID: 22339127

6

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.

Xiang Y, Hirth B, Asmussen G, Biemann HP, Bishop KA, Good A, Fitzgerald M, Gladysheva T, Jain A, Jancsics K, Liu J, Metz M, Papoulis A, Skerlj R, Stepp JD, Wei RR. Xiang Y, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):3050-6. doi: 10.1016/j.bmcl.2011.03.030. Epub 2011 Mar 16. Bioorg Med Chem Lett. 2011. PMID: 21507633

7

Identification of N2-(1-carboxymethyl)guanine (CMG) as a guanine advanced glycation end product.

al-Abed Y, Schleicher E, Voelter W, Liebich H, Papoulis A, Bucala R. al-Abed Y, et al. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2109-10. doi: 10.1016/s0960-894x(98)00398-9. Bioorg Med Chem Lett. 1998. PMID: 9873495

8

Identification of N2-(1-carboxyethyl)guanine (CEG) as a guanine advanced glycosylation end product.

Papoulis A, al-Abed Y, Bucala R. Papoulis A, et al. Biochemistry. 1995 Jan 17;34(2):648-55. doi: 10.1021/bi00002a032. Biochemistry. 1995. PMID: 7819260

9

GT160-246, a toxin binding polymer for treatment of Clostridium difficile colitis.

Kurtz CB, Cannon EP, Brezzani A, Pitruzzello M, Dinardo C, Rinard E, Acheson DW, Fitzpatrick R, Kelly P, Shackett K, Papoulis AT, Goddard PJ, Barker RH Jr, Palace GP, Klinger JD. Kurtz CB, et al. Among authors: papoulis at. Antimicrob Agents Chemother. 2001 Aug;45(8):2340-7. doi: 10.1128/AAC.45.8.2340-2347.2001. Antimicrob Agents Chemother. 2001. PMID: 11451694 Free PMC article.

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