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Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand.
J Med Chem. 1999 Dec 30;42(26):5359-68. doi: 10.1021/jm990337f.
J Med Chem. 1999.
PMID: 10639279
Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographical constraints in peptide design.
Alfaro-Lopez J, Yuan W, Phan BC, Kamath J, Lou Q, Lam KS, Hruby VJ.
Alfaro-Lopez J, et al.
J Med Chem. 1998 Jun 18;41(13):2252-60. doi: 10.1021/jm9707885.
J Med Chem. 1998.
PMID: 9632358
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De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.
Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI, Hruby VJ.
Liao S, et al. Among authors: alfaro lopez j.
J Med Chem. 1998 Nov 19;41(24):4767-76. doi: 10.1021/jm980374r.
J Med Chem. 1998.
PMID: 9822547
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(2S,3R) beta-methyl-2',6'-dimethyltyrosine-L-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-L-Tic-OH] is a potent, selective delta-opioid receptor antagonist in mouse brain.
Hosohata K, Varga EV, Alfaro-Lopez J, Tang X, Vanderah TW, Porreca F, Hruby VJ, Roeske WR, Yamamura HI.
Hosohata K, et al. Among authors: alfaro lopez j.
J Pharmacol Exp Ther. 2003 Feb;304(2):683-8. doi: 10.1124/jpet.102.042929.
J Pharmacol Exp Ther. 2003.
PMID: 12538822
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Endomorphin-1 and endomorphin-2 are partial agonists at the human mu-opioid receptor.
Hosohata K, Burkey TH, Alfaro-Lopez J, Varga E, Hruby VJ, Roeske WR, Yamamura HI.
Hosohata K, et al. Among authors: alfaro lopez j.
Eur J Pharmacol. 1998 Apr 3;346(1):111-4. doi: 10.1016/s0014-2999(98)00117-4.
Eur J Pharmacol. 1998.
PMID: 9617760
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(2S,3R)TMT-L-Tic-OH is a potent inverse agonist at the human delta-opioid receptor.
Hosohata K, Burkey TH, Alfaro-Lopez J, Hruby VJ, Roeske WR, Yamamura HI.
Hosohata K, et al. Among authors: alfaro lopez j.
Eur J Pharmacol. 1999 Sep 3;380(1):R9-10. doi: 10.1016/s0014-2999(99)00516-6.
Eur J Pharmacol. 1999.
PMID: 10513562
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Peptide-lisinopril conjugates: design, synthesis and biological activities.
Alfaro-Lopez J, Soares C, Ghosh S, Kravchuk A, Coates E, Jodka L, Carroll A, Liu Q.
Alfaro-Lopez J, et al.
Adv Exp Med Biol. 2009;611:535-6. doi: 10.1007/978-0-387-73657-0_234.
Adv Exp Med Biol. 2009.
PMID: 19400301
No abstract available.
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