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LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome.
Volikos E, Robinson J, Aittomäki K, Mecklin JP, Järvinen H, Westerman AM, de Rooji FW, Vogel T, Moeslein G, Launonen V, Tomlinson IP, Silver AR, Aaltonen LA. Volikos E, et al. Among authors: mecklin jp. J Med Genet. 2006 May;43(5):e18. doi: 10.1136/jmg.2005.039875. J Med Genet. 2006. PMID: 16648371 Free PMC article.
Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis.
Laiho P, Kokko A, Vanharanta S, Salovaara R, Sammalkorpi H, Järvinen H, Mecklin JP, Karttunen TJ, Tuppurainen K, Davalos V, Schwartz S Jr, Arango D, Mäkinen MJ, Aaltonen LA. Laiho P, et al. Among authors: mecklin jp. Oncogene. 2007 Jan 11;26(2):312-20. doi: 10.1038/sj.onc.1209778. Epub 2006 Jul 3. Oncogene. 2007. PMID: 16819509
307 results