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Heparin inhibits the binding of beta 2-glycoprotein I to phospholipids and promotes the plasmin-mediated inactivation of this blood protein. Elucidation of the consequences of the two biological events in patients with the anti-phospholipid syndrome.
Guerin J, Sheng Y, Reddel S, Iverson GM, Chapman MG, Krilis SA. Guerin J, et al. J Biol Chem. 2002 Jan 25;277(4):2644-9. doi: 10.1074/jbc.M110176200. Epub 2001 Nov 15. J Biol Chem. 2002. PMID: 11711550 Free article.
Detection of 'antiphospholipid' antibodies: a single chromogenic assay of thrombin generation sensitively detects lupus anticoagulants, anticardiolipin antibodies, plus antibodies binding beta(2)-glycoprotein I and prothrombin.
Sheng Y, Hanly JG, Reddel SW, Kouts S, Guerin J, Koike T, Ichikawa K, Sturgess A, Krilis SA. Sheng Y, et al. Among authors: guerin j. Clin Exp Immunol. 2001 Jun;124(3):502-8. doi: 10.1046/j.1365-2249.2001.01555.x. Clin Exp Immunol. 2001. PMID: 11472415 Free PMC article.
882 results