Hirao A - Search Results

1

DNA damage-induced activation of p53 by the checkpoint kinase Chk2.

Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, Liu D, Elledge SJ, Mak TW. Hirao A, et al. Science. 2000 Mar 10;287(5459):1824-7. doi: 10.1126/science.287.5459.1824. Science. 2000. PMID: 10710310

2

ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53.

Tang D, Wu D, Hirao A, Lahti JM, Liu L, Mazza B, Kidd VJ, Mak TW, Ingram AJ. Tang D, et al. Among authors: hirao a. J Biol Chem. 2002 Apr 12;277(15):12710-7. doi: 10.1074/jbc.M111598200. Epub 2002 Jan 30. J Biol Chem. 2002. PMID: 11821415 Free article.

3

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response.

Jack MT, Woo RA, Hirao A, Cheung A, Mak TW, Lee PW. Jack MT, et al. Among authors: hirao a. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9825-9. doi: 10.1073/pnas.152053599. Epub 2002 Jul 3. Proc Natl Acad Sci U S A. 2002. PMID: 12097646 Free PMC article.

4

Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila.

Peters M, DeLuca C, Hirao A, Stambolic V, Potter J, Zhou L, Liepa J, Snow B, Arya S, Wong J, Bouchard D, Binari R, Manoukian AS, Mak TW. Peters M, et al. Among authors: hirao a. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11305-10. doi: 10.1073/pnas.172382899. Epub 2002 Aug 9. Proc Natl Acad Sci U S A. 2002. PMID: 12172011 Free PMC article.

5

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.

Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, Elledge SJ, Mak TW. Hirao A, et al. Mol Cell Biol. 2002 Sep;22(18):6521-32. doi: 10.1128/MCB.22.18.6521-6532.2002. Mol Cell Biol. 2002. PMID: 12192050 Free PMC article.

6

Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.

Cheung AM, Hande MP, Jalali F, Tsao MS, Skinnider B, Hirao A, McPherson JP, Karaskova J, Suzuki A, Wakeham A, You-Ten A, Elia A, Squire J, Bristow R, Hakem R, Mak TW. Cheung AM, et al. Among authors: hirao a. Cancer Res. 2002 Nov 1;62(21):6194-204. Cancer Res. 2002. PMID: 12414647

7

Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.

Keramaris E, Hirao A, Slack RS, Mak TW, Park DS. Keramaris E, et al. Among authors: hirao a. J Biol Chem. 2003 Sep 26;278(39):37782-9. doi: 10.1074/jbc.M304049200. Epub 2003 Jul 11. J Biol Chem. 2003. PMID: 12857758 Free article.

8

Collaboration of Brca1 and Chk2 in tumorigenesis.

McPherson JP, Lemmers B, Hirao A, Hakem A, Abraham J, Migon E, Matysiak-Zablocki E, Tamblyn L, Sanchez-Sweatman O, Khokha R, Squire J, Hande MP, Mak TW, Hakem R. McPherson JP, et al. Among authors: hirao a. Genes Dev. 2004 May 15;18(10):1144-53. doi: 10.1101/gad.1192704. Epub 2004 May 6. Genes Dev. 2004. PMID: 15131084 Free PMC article.

9

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells.

Ito K, Hirao A, Arai F, Matsuoka S, Takubo K, Hamaguchi I, Nomiyama K, Hosokawa K, Sakurada K, Nakagata N, Ikeda Y, Mak TW, Suda T. Ito K, et al. Among authors: hirao a. Nature. 2004 Oct 21;431(7011):997-1002. doi: 10.1038/nature02989. Nature. 2004. PMID: 15496926

10

Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.

Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa K, Ikeda Y, Mak TW, Suda T, Hirao A. Ito K, et al. Among authors: hirao a. J Immunol. 2007 Jan 1;178(1):103-10. doi: 10.4049/jimmunol.178.1.103. J Immunol. 2007. PMID: 17182545

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