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Study on selectin blocker. 8. Lead discovery of a non-sugar antagonist using a 3D-pharmacophore model.
Hiramatsu Y, Tsukida T, Nakai Y, Inoue Y, Kondo H. Hiramatsu Y, et al. Among authors: kondo h. J Med Chem. 2000 Apr 20;43(8):1476-83. doi: 10.1021/jm990342j. J Med Chem. 2000. PMID: 10780903
In a series of sugar mimetic studies of the E-selectin ligand, sialyl Lewis X (sLe(x)), we have already found a potent compound, a sulfated Le(x) analogue (1), and also have proposed how compound 1 binds to E-selectin (Tsujishita, H.; Hiramatsu, Y.; Kondo, N.; Ohmot …
In a series of sugar mimetic studies of the E-selectin ligand, sialyl Lewis X (sLe(x)), we have already found a potent compound, a sulfated …
Studies on selectin blockers. 7. Structure-activity relationships of sialyl Lewis X mimetics based on modified Ser-Glu dipeptides.
Tsukida T, Moriyama H, Kurokawa K, Achiha T, Inoue Y, Kondo H. Tsukida T, et al. Among authors: kondo h. J Med Chem. 1998 Oct 22;41(22):4279-87. doi: 10.1021/jm980267x. J Med Chem. 1998. PMID: 9784103
We have previously found that heterochiral fucodipeptides, L-Ser-D-Glu (3a) and D-Ser-L-Glu (3b), exhibited up to 20-100 times more potency than a sialyl Lewis X (sLeX, 1) and a 3'-sulfated Lewis X analogue (2) toward E-selectin binding and have also proposed, from molecular dyna …
We have previously found that heterochiral fucodipeptides, L-Ser-D-Glu (3a) and D-Ser-L-Glu (3b), exhibited up to 20-100 times more potency …
Studies on selectin blocker. 9. SARs of non-sugar selectin blocker against E-, P-, L-selectin bindings.
Moriyama H, Hiramatsu Y, Kiyoi T, Achiha T, Inoue Y, Kondo H. Moriyama H, et al. Among authors: kondo h. Bioorg Med Chem. 2001 Jun;9(6):1479-91. doi: 10.1016/s0968-0896(01)00023-2. Bioorg Med Chem. 2001. PMID: 11408166
As a part of study of selectin blockers, we have already reported that a non-sugar selectin antagonist (3) was successfully discovered using a computational screening (Hiramatsu, Y.; Tsukida, T.; Nakai, Y.; Inoue, Y.; Kondo, H. J. Med. Chem. 2000, 43, 1476). To inve …
As a part of study of selectin blockers, we have already reported that a non-sugar selectin antagonist (3) was successfully discovered using …
3,674 results