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Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia.
Davis JB, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K, Hughes SA, Rance K, Grau E, Harper AJ, Pugh PL, Rogers DC, Bingham S, Randall A, Sheardown SA. Davis JB, et al. Among authors: sheardown sa. Nature. 2000 May 11;405(6783):183-7. doi: 10.1038/35012076. Nature. 2000. PMID: 10821274
Requirement for Xist in X chromosome inactivation.
Penny GD, Kay GF, Sheardown SA, Rastan S, Brockdorff N. Penny GD, et al. Among authors: sheardown sa. Nature. 1996 Jan 11;379(6561):131-7. doi: 10.1038/379131a0. Nature. 1996. PMID: 8538762
The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors.
Thuault SJ, Brown JT, Sheardown SA, Jourdain S, Fairfax B, Spencer JP, Restituito S, Nation JH, Topps S, Medhurst AD, Randall AD, Couve A, Moss SJ, Collingridge GL, Pangalos MN, Davies CH, Calver AR. Thuault SJ, et al. Among authors: sheardown sa. Biochem Pharmacol. 2004 Oct 15;68(8):1655-66. doi: 10.1016/j.bcp.2004.07.032. Biochem Pharmacol. 2004. PMID: 15451409
Towards a mutant map of the mouse--new models of neurological, behavioural, deafness, bone, renal and blood disorders.
Rastan S, Hough T, Kierman A, Hardisty R, Erven A, Gray IC, Voeling S, Isaacs A, Tsai H, Strivens M, Washbourne R, Thornton C, Greenaway S, Hewitt M, McCormick S, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Mburu P, Rogers D, Hagan J, Reavill C, Davies K, Glenister P, Fisher EM, Martin J, Vizor L, Bouzyk M, Kelsell D, Guenet JL, Steel KP, Sheardown S, Spurr N, Gray I, Peters J, Nolan PM, Hunter AJ, Brown SD. Rastan S, et al. Genetica. 2004 Sep;122(1):47-9. doi: 10.1007/s10709-004-1930-x. Genetica. 2004. PMID: 15619960
N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I.
Thorneloe KS, Sulpizio AC, Lin Z, Figueroa DJ, Clouse AK, McCafferty GP, Chendrimada TP, Lashinger ES, Gordon E, Evans L, Misajet BA, Demarini DJ, Nation JH, Casillas LN, Marquis RW, Votta BJ, Sheardown SA, Xu X, Brooks DP, Laping NJ, Westfall TD. Thorneloe KS, et al. Among authors: sheardown sa. J Pharmacol Exp Ther. 2008 Aug;326(2):432-42. doi: 10.1124/jpet.108.139295. Epub 2008 May 22. J Pharmacol Exp Ther. 2008. PMID: 18499743
29 results