Relling MV - Search Results

1

Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein.

Brimer C, Dalton JT, Zhu Z, Schuetz J, Yasuda K, Vanin E, Relling MV, Lu Y, Schuetz EG. Brimer C, et al. Among authors: relling mv. Pharm Res. 2000 Jul;17(7):803-10. doi: 10.1023/a:1007599923694. Pharm Res. 2000. PMID: 10990198

2

Variability in human cytochrome P450 paclitaxel metabolism.

Sonnichsen DS, Liu Q, Schuetz EG, Schuetz JD, Pappo A, Relling MV. Sonnichsen DS, et al. Among authors: relling mv. J Pharmacol Exp Ther. 1995 Nov;275(2):566-75. J Pharmacol Exp Ther. 1995. PMID: 7473140

3

A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase.

Krynetski EY, Schuetz JD, Galpin AJ, Pui CH, Relling MV, Evans WE. Krynetski EY, et al. Among authors: relling mv. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):949-53. doi: 10.1073/pnas.92.4.949. Proc Natl Acad Sci U S A. 1995. PMID: 7862671 Free PMC article.

4

O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4.

Relling MV, Nemec J, Schuetz EG, Schuetz JD, Gonzalez FJ, Korzekwa KR. Relling MV, et al. Mol Pharmacol. 1994 Feb;45(2):352-8. Mol Pharmacol. 1994. PMID: 8114683

5

Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate.

Masson E, Relling MV, Synold TW, Liu Q, Schuetz JD, Sandlund JT, Pui CH, Evans WE. Masson E, et al. Among authors: relling mv. J Clin Invest. 1996 Jan 1;97(1):73-80. doi: 10.1172/JCI118409. J Clin Invest. 1996. PMID: 8550853 Free PMC article. Clinical Trial.

6

Allopurinol inhibits de novo purine synthesis in lymphoblasts of children with acute lymphoblastic leukemia.

Masson E, Synold TW, Relling MV, Schuetz JD, Sandlund JT, Pui CH, Evans WE. Masson E, et al. Among authors: relling mv. Leukemia. 1996 Jan;10(1):56-60. Leukemia. 1996. PMID: 8558939 Clinical Trial.

7

P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans.

Schuetz EG, Schinkel AH, Relling MV, Schuetz JD. Schuetz EG, et al. Among authors: relling mv. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4001-5. doi: 10.1073/pnas.93.9.4001. Proc Natl Acad Sci U S A. 1996. PMID: 8633005 Free PMC article.

8

Are the major effects of P-glycoprotein modulators due to altered pharmacokinetics of anticancer drugs?

Relling MV. Relling MV. Ther Drug Monit. 1996 Aug;18(4):350-6. doi: 10.1097/00007691-199608000-00006. Ther Drug Monit. 1996. PMID: 8857549

9

Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.

Krynetski EY, Tai HL, Yates CR, Fessing MY, Loennechen T, Schuetz JD, Relling MV, Evans WE. Krynetski EY, et al. Among authors: relling mv. Pharmacogenetics. 1996 Aug;6(4):279-90. doi: 10.1097/00008571-199608000-00001. Pharmacogenetics. 1996. PMID: 8873214 Review.

10

Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity.

Galpin AJ, Schuetz JD, Masson E, Yanishevski Y, Synold TW, Barredo JC, Pui CH, Relling MV, Evans WE. Galpin AJ, et al. Among authors: relling mv. Mol Pharmacol. 1997 Jul;52(1):155-63. doi: 10.1124/mol.52.1.155. Mol Pharmacol. 1997. PMID: 9224825

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