Lum R - Search Results

1

Dibasic inhibitors of human mast cell tryptase. Part 1: synthesis and optimization of a novel class of inhibitors.

Rice KD, Gangloff AR, Kuo EY, Dener JM, Wang VR, Lum R, Newcomb WS, Havel C, Putnam D, Cregar L, Wong M, Warne RL. Rice KD, et al. Among authors: lum r. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2357-60. doi: 10.1016/s0960-894x(00)00484-4. Bioorg Med Chem Lett. 2000. PMID: 11055355

2

Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides.

Lum RT, Nelson MG, Joly A, Horsma AG, Lee G, Meyer SM, Wick MM, Schow SR. Lum RT, et al. Bioorg Med Chem Lett. 1998 Feb 3;8(3):209-14. doi: 10.1016/s0960-894x(98)00015-8. Bioorg Med Chem Lett. 1998. PMID: 9871656

3

5-Substituted isophthalamides as insulin receptor sensitizers.

Robinson L, Bajjalieh S, Cairns N, Lum RT, Macsata RW, Manchem VP, Park SJ, Rao S, Schow SR, Shi S, Spevak WR. Robinson L, et al. Among authors: lum rt. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3492-4. doi: 10.1016/j.bmcl.2008.05.031. Epub 2008 May 15. Bioorg Med Chem Lett. 2008. PMID: 18513965

4

Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.

Hsu N, Cai D, Damodaran K, Gomez RF, Keck JG, Laborde E, Lum RT, Macke TJ, Martin G, Schow SR, Simon RJ, Villar HO, Wick MM, Beroza P. Hsu N, et al. Among authors: lum rt. J Med Chem. 2004 Sep 23;47(20):4875-80. doi: 10.1021/jm049950b. J Med Chem. 2004. PMID: 15369391

5

Design, synthesis, and structure-activity relationships of novel insulin receptor tyrosine kinase activators.

Lum RT, Cheng M, Cristobal CP, Goldfine ID, Evans JL, Keck JG, Macsata RW, Manchem VP, Matsumoto Y, Park SJ, Rao SS, Robinson L, Shi S, Spevak WR, Schow SR. Lum RT, et al. J Med Chem. 2008 Oct 9;51(19):6173-87. doi: 10.1021/jm800600v. Epub 2008 Sep 13. J Med Chem. 2008. PMID: 18788731

6

Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.

Pfister JR, Belardinelli L, Lee G, Lum RT, Milner P, Stanley WC, Linden J, Baker SP, Schreiner G. Pfister JR, et al. Among authors: lum rt. J Med Chem. 1997 Jun 6;40(12):1773-8. doi: 10.1021/jm970013w. J Med Chem. 1997. PMID: 9191953

7

A new structural class of proteasome inhibitors that prevent NF-kappa B activation.

Lum RT, Kerwar SS, Meyer SM, Nelson MG, Schow SR, Shiffman D, Wick MM, Joly A. Lum RT, et al. Biochem Pharmacol. 1998 May 1;55(9):1391-7. doi: 10.1016/s0006-2952(97)00655-2. Biochem Pharmacol. 1998. PMID: 10076530

8

Target-related affinity profiling: Telik's lead discovery technology.

Beroza P, Damodaran K, Lum RT. Beroza P, et al. Curr Top Med Chem. 2005;5(4):371-81. doi: 10.2174/1568026053828394. Curr Top Med Chem. 2005. PMID: 15892680 Review.

9

In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator.

Cheng M, Chen S, Schow SR, Manchem VP, Spevak WR, Cristobal CP, Shi S, Macsata RW, Lum RT, Goldfine ID, Keck JG. Cheng M, et al. Among authors: lum rt. J Cell Biochem. 2004 Aug 15;92(6):1234-45. doi: 10.1002/jcb.20150. J Cell Biochem. 2004. PMID: 15258906

10

CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation.

Brooks EE, Gray NS, Joly A, Kerwar SS, Lum R, Mackman RL, Norman TC, Rosete J, Rowe M, Schow SR, Schultz PG, Wang X, Wick MM, Shiffman D. Brooks EE, et al. Among authors: lum r. J Biol Chem. 1997 Nov 14;272(46):29207-11. doi: 10.1074/jbc.272.46.29207. J Biol Chem. 1997. PMID: 9360999 Free article.

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