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Expression and characterization of truncated forms of humanized L243 IgG1. Architectural features can influence synthesis of its oligosaccharide chains and affect superoxide production triggered through human Fcgamma receptor I.
Lund J, Takahashi N, Popplewell A, Goodall M, Pound JD, Tyler R, King DJ, Jefferis R. Lund J, et al. Among authors: popplewell a. Eur J Biochem. 2000 Dec;267(24):7246-57. doi: 10.1046/j.1432-1327.2000.01839.x. Eur J Biochem. 2000. PMID: 11106438 Free article.
In vitro and in vivo characterisation of anti-murine IL-13 antibodies recognising distinct functional epitopes.
Berry LM, Adams R, Airey M, Bracher MG, Bourne T, Carrington B, Cross AS, Davies GC, Finney HM, Foulkes R, Gozzard N, Griffin RA, Hailu H, Lamour SD, Lawson AD, Lightwood DJ, McKnight AJ, O'Dowd VL, Oxbrow AK, Popplewell AG, Shaw S, Stephens PE, Sweeney B, Tomlinson KL, Uhe C, Palframan RT. Berry LM, et al. Among authors: popplewell ag. Int Immunopharmacol. 2009 Feb;9(2):201-6. doi: 10.1016/j.intimp.2008.11.001. Epub 2008 Nov 27. Int Immunopharmacol. 2009. PMID: 19041426
Prolonged in vivo residence times of antibody fragments associated with albumin.
Smith BJ, Popplewell A, Athwal D, Chapman AP, Heywood S, West SM, Carrington B, Nesbitt A, Lawson AD, Antoniw P, Eddelston A, Suitters A. Smith BJ, et al. Among authors: popplewell a. Bioconjug Chem. 2001 Sep-Oct;12(5):750-6. doi: 10.1021/bc010003g. Bioconjug Chem. 2001. PMID: 11562193
Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans.
Rijal P, Elias SC, Machado SR, Xiao J, Schimanski L, O'Dowd V, Baker T, Barry E, Mendelsohn SC, Cherry CJ, Jin J, Labbé GM, Donnellan FR, Rampling T, Dowall S, Rayner E, Findlay-Wilson S, Carroll M, Guo J, Xu XN, Huang KA, Takada A, Burgess G, McMillan D, Popplewell A, Lightwood DJ, Draper SJ, Townsend AR. Rijal P, et al. Among authors: popplewell a. Cell Rep. 2019 Apr 2;27(1):172-186.e7. doi: 10.1016/j.celrep.2019.03.020. Cell Rep. 2019. PMID: 30943399 Free article. Clinical Trial.
Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau.
Courade JP, Angers R, Mairet-Coello G, Pacico N, Tyson K, Lightwood D, Munro R, McMillan D, Griffin R, Baker T, Starkie D, Nan R, Westwood M, Mushikiwabo ML, Jung S, Odede G, Sweeney B, Popplewell A, Burgess G, Downey P, Citron M. Courade JP, et al. Among authors: popplewell a. Acta Neuropathol. 2018 Nov;136(5):729-745. doi: 10.1007/s00401-018-1911-2. Epub 2018 Sep 20. Acta Neuropathol. 2018. PMID: 30238240 Free PMC article.
32 results