De Clercq E - Search Results

1

Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores.

Santhosh KC, Paul GC, De Clercq E, Pannecouque C, Witvrouw M, Loftus TL, Turpin JA, Buckheit RW Jr, Cushman M. Santhosh KC, et al. Among authors: de clercq e. J Med Chem. 2001 Mar 1;44(5):703-14. doi: 10.1021/jm000290u. J Med Chem. 2001. PMID: 11262081

2

Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: direct correlation of antiviral potency with molecular weight.

Cushman M, Wang PL, Chang SH, Wild C, De Clercq E, Schols D, Goldman ME, Bowen JA. Cushman M, et al. Among authors: de clercq e. J Med Chem. 1991 Jan;34(1):329-37. doi: 10.1021/jm00105a052. J Med Chem. 1991. PMID: 1704065

3

Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds.

Cushman M, Kanamathareddy S, De Clercq E, Schols D, Goldman ME, Bowen JA. Cushman M, et al. Among authors: de clercq e. J Med Chem. 1991 Jan;34(1):337-42. doi: 10.1021/jm00105a053. J Med Chem. 1991. PMID: 1704066

4

Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.

Cushman M, Golebiewski WM, Pommier Y, Mazumder A, Reymen D, De Clercq E, Graham L, Rice WG. Cushman M, et al. Among authors: de clercq e. J Med Chem. 1995 Feb 3;38(3):443-52. doi: 10.1021/jm00003a007. J Med Chem. 1995. PMID: 7853337

5

Chicoric acid analogues as HIV-1 integrase inhibitors.

Lin Z, Neamati N, Zhao H, Kiryu Y, Turpin JA, Aberham C, Strebel K, Kohn K, Witvrouw M, Pannecouque C, Debyser Z, De Clercq E, Rice WG, Pommier Y, Burke TR Jr. Lin Z, et al. Among authors: de clercq e. J Med Chem. 1999 Apr 22;42(8):1401-14. doi: 10.1021/jm980531m. J Med Chem. 1999. PMID: 10212126

6

Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency.

Cushman M, Insaf S, Paul G, Ruell JA, De Clercq E, Schols D, Pannecouque C, Witvrouw M, Schaeffer CA, Turpin JA, Williamson K, Rice WG. Cushman M, et al. Among authors: de clercq e. J Med Chem. 1999 May 20;42(10):1767-77. doi: 10.1021/jm980727m. J Med Chem. 1999. PMID: 10346929

7

Potent anti-HIV (type 1 and type 2) activity of polyoxometalates: structure-activity relationship and mechanism of action.

Witvrouw M, Weigold H, Pannecouque C, Schols D, De Clercq E, Holan G. Witvrouw M, et al. Among authors: de clercq e. J Med Chem. 2000 Mar 9;43(5):778-83. doi: 10.1021/jm980263s. J Med Chem. 2000. PMID: 10715146

8

Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain.

Casimiro-Garcia A, De Clercq E, Pannecouque C, Witvrouw M, Stup TL, Turpin JA, Buckheit RW Jr, Cushman M. Casimiro-Garcia A, et al. Among authors: de clercq e. Bioorg Med Chem. 2000 Jan;8(1):191-200. doi: 10.1016/s0968-0896(99)00269-2. Bioorg Med Chem. 2000. PMID: 10968278

There are several steps in the HIV replication cycle that have been proposed as targets for the development of therapeutic agents (De Clercq, E. J. Med. Chem. 1995, 38, 2491; De Clercq, E. Pure Appl. ...

There are several steps in the HIV replication cycle that have been proposed as targets for the development of therapeutic agents (De …

9

Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates.

Paul GC, De Clercq E, Pannecouque C, Witvrouw M, Loftus TL, Turpin JA, Buckheit RW Jr, Cushman M. Paul GC, et al. Among authors: de clercq e. Bioorg Med Chem Lett. 2000 Sep 18;10(18):2149-52. doi: 10.1016/s0960-894x(00)00417-0. Bioorg Med Chem Lett. 2000. PMID: 10999491

10

Anti-HIV activity of a series of cosalane amino acid conjugates.

Santhosh KC, De Clercq E, Pannecouque C, Witvrouw M, Loftus TL, Turpin JA, Buckheit RW, Cushman M. Santhosh KC, et al. Among authors: de clercq e. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2505-8. doi: 10.1016/s0960-894x(00)00515-1. Bioorg Med Chem Lett. 2000. PMID: 11086716

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