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Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead.
Liu G, Link JT, Pei Z, Reilly EB, Leitza S, Nguyen B, Marsh KC, Okasinski GF, von Geldern TW, Ormes M, Fowler K, Gallatin M. Liu G, et al. J Med Chem. 2000 Oct 19;43(21):4025-40. doi: 10.1021/jm0002782. J Med Chem. 2000. PMID: 11052808
Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides.
Pei Z, Xin Z, Liu G, Li Y, Reilly EB, Lubbers NL, Huth JR, Link JT, von Geldern TW, Cox BF, Leitza S, Gao Y, Marsh KC, DeVries P, Okasinski GF. Pei Z, et al. Among authors: liu g. J Med Chem. 2001 Aug 30;44(18):2913-20. doi: 10.1021/jm010059w. J Med Chem. 2001. PMID: 11520199
Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure-activity relationship of substituents on the benzene ring of the cinnamide.
Winn M, Reilly EB, Liu G, Huth JR, Jae HS, Freeman J, Pei Z, Xin Z, Lynch J, Kester J, von Geldern TW, Leitza S, DeVries P, Dickinson R, Mussatto D, Okasinski GF. Winn M, et al. Among authors: liu g. J Med Chem. 2001 Dec 6;44(25):4393-403. doi: 10.1021/jm0103108. J Med Chem. 2001. PMID: 11728185
Potent, selective inhibitors of protein tyrosine phosphatase 1B.
Xin Z, Oost TK, Abad-Zapatero C, Hajduk PJ, Pei Z, Szczepankiewicz BG, Hutchins CW, Ballaron SJ, Stashko MA, Lubben T, Trevillyan JM, Jirousek MR, Liu G. Xin Z, et al. Among authors: liu g. Bioorg Med Chem Lett. 2003 Jun 2;13(11):1887-90. doi: 10.1016/s0960-894x(03)00302-0. Bioorg Med Chem Lett. 2003. PMID: 12749891
Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
Zhao H, Liu G, Xin Z, Serby MD, Pei Z, Szczepankiewicz BG, Hajduk PJ, Abad-Zapatero C, Hutchins CW, Lubben TH, Ballaron SJ, Haasch DL, Kaszubska W, Rondinone CM, Trevillyan JM, Jirousek MR. Zhao H, et al. Among authors: liu g. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5543-6. doi: 10.1016/j.bmcl.2004.08.063. Bioorg Med Chem Lett. 2004. PMID: 15482920
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