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Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.
Bioorg Med Chem Lett. 2001 Jun 4;11(11):1411-5. doi: 10.1016/s0960-894x(01)00240-2.
Bioorg Med Chem Lett. 2001.
PMID: 11378366
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.
Omer CA, Chen Z, Diehl RE, Conner MW, Chen HY, Trumbauer ME, Gopal-Truter S, Seeburger G, Bhimnathwala H, Abrams MT, Davide JP, Ellis MS, Gibbs JB, Greenberg I, Koblan KS, Kral AM, Liu D, Lobell RB, Miller PJ, Mosser SD, O'Neill TJ, Rands E, Schaber MD, Senderak ET, Oliff A, Kohl NE.
Omer CA, et al.
Cancer Res. 2000 May 15;60(10):2680-8.
Cancer Res. 2000.
PMID: 10825141
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High-performance liquid chromatography/mass spectrometry characterization of Ki4B-Ras in PSN-1 cells treated with the prenyltransferase inhibitor L-778,123.
Buser CA, Dinsmore CJ, Fernandes C, Greenberg I, Hamilton K, Mosser SD, Walsh ES, Williams TM, Koblan KS.
Buser CA, et al.
Anal Biochem. 2001 Mar 1;290(1):126-37. doi: 10.1006/abio.2000.4972.
Anal Biochem. 2001.
PMID: 11180946
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N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.
Williams TM, Bergman JM, Brashear K, Breslin MJ, Dinsmore CJ, Hutchinson JH, MacTough SC, Stump CA, Wei DD, Zartman CB, Bogusky MJ, Culberson JC, Buser-Doepner C, Davide J, Greenberg IB, Hamilton KA, Koblan KS, Kohl NE, Liu D, Lobell RB, Mosser SD, O'Neill TJ, Rands E, Schaber MD, Huff JR, et al.
Williams TM, et al. Among authors: greenberg ib.
J Med Chem. 1999 Sep 23;42(19):3779-84. doi: 10.1021/jm990254z.
J Med Chem. 1999.
PMID: 10508426
No abstract available.
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Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase.
Dinsmore CJ, Bergman JM, Wei DD, Zartman CB, Davide JP, Greenberg IB, Liu D, O'Neill TJ, Gibbs JB, Koblan KS, Kohl NE, Lobell RB, Chen IW, McLoughlin DA, Olah TV, Graham SL, Hartman GD, Williams TM.
Dinsmore CJ, et al. Among authors: greenberg ib.
Bioorg Med Chem Lett. 2001 Feb 26;11(4):537-40. doi: 10.1016/s0960-894x(00)00710-1.
Bioorg Med Chem Lett. 2001.
PMID: 11229765
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Transgene-coded chimeric proteins as reporters of intracellular proteolysis: starvation-induced catabolism of a lacZ fusion protein in muscle cells of Caenorhabditis elegans.
Zdinak LA, Greenberg IB, Szewczyk NJ, Barmada SJ, Cardamone-Rayner M, Hartman JJ, Jacobson LA.
Zdinak LA, et al. Among authors: greenberg ib.
J Cell Biochem. 1997 Oct 1;67(1):143-53.
J Cell Biochem. 1997.
PMID: 9328848
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