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Structural aspects of interfacial adsorption. A crystallographic and site-directed mutagenesis study of the phospholipase A2 from the venom of Agkistrodon piscivorus piscivorus.
Han SK, Yoon ET, Scott DL, Sigler PB, Cho W. Han SK, et al. Among authors: cho w. J Biol Chem. 1997 Feb 7;272(6):3573-82. J Biol Chem. 1997. PMID: 9013608 Free article.
Efficient and productive adsorption of the Class I bovine pancreatic phospholipase A2 to anionic interfaces is dependent upon the presence of two nonconserved lysine residues at sequence positions 56 and 116, implying that critical components of the adsorption surface differ amon …
Efficient and productive adsorption of the Class I bovine pancreatic phospholipase A2 to anionic interfaces is dependent upon the presence o …
A structure-function study of the C2 domain of cytosolic phospholipase A2. Identification of essential calcium ligands and hydrophobic membrane binding residues.
Bittova L, Sumandea M, Cho W. Bittova L, et al. Among authors: cho w. J Biol Chem. 1999 Apr 2;274(14):9665-72. doi: 10.1074/jbc.274.14.9665. J Biol Chem. 1999. PMID: 10092653 Free article.
In conjunction with our previous study on the C2 domain of protein kinase C-alpha (Medkova, M., and Cho, W. (1998) J. Biol. Chem. 273, 17544-17552), these results demonstrate that C2 domains are not only a membrane docking unit but also a module that triggers membra …
In conjunction with our previous study on the C2 domain of protein kinase C-alpha (Medkova, M., and Cho, W. (1998) J. Biol. Ch …
Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2.
Han SK, Kim KP, Koduri R, Bittova L, Munoz NM, Leff AR, Wilton DC, Gelb MH, Cho W. Han SK, et al. Among authors: cho w. J Biol Chem. 1999 Apr 23;274(17):11881-8. doi: 10.1074/jbc.274.17.11881. J Biol Chem. 1999. PMID: 10207008 Free article.
We have demonstrated that human group V PLA2 (hsPLA2-V) can bind phosphatidylcholine (PC) membranes and hydrolyze PC substrates much more efficiently than human group IIa PLA2, which makes it better suited for acting on the outer plasma membrane (Han, S.-K., Yoon, E. T., and C …
We have demonstrated that human group V PLA2 (hsPLA2-V) can bind phosphatidylcholine (PC) membranes and hydrolyze PC substrates much more ef …
Interplay of C1 and C2 domains of protein kinase C-alpha in its membrane binding and activation.
Medkova M, Cho W. Medkova M, et al. Among authors: cho w. J Biol Chem. 1999 Jul 9;274(28):19852-61. doi: 10.1074/jbc.274.28.19852. J Biol Chem. 1999. PMID: 10391930 Free article.
Based on these results in conjunction with our previous structure-function studies of the C2 domain (Medkova, M., and Cho, W. (1998) J. Biol. Chem. 273, 17544-17552), we propose a mechanism for the in vitro membrane binding and activation of conventional PKC that ac …
Based on these results in conjunction with our previous structure-function studies of the C2 domain (Medkova, M., and Cho, W. …
3,833 results