Debnath ML - Search Results

1

A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.

Mathis CA, Bacskai BJ, Kajdasz ST, McLellan ME, Frosch MP, Hyman BT, Holt DP, Wang Y, Huang GF, Debnath ML, Klunk WE. Mathis CA, et al. Among authors: debnath ml. Bioorg Med Chem Lett. 2002 Feb 11;12(3):295-8. doi: 10.1016/s0960-894x(01)00734-x. Bioorg Med Chem Lett. 2002. PMID: 11814781

2

Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease.

Wang Y, Klunk WE, Huang GF, Debnath ML, Holt DP, Mathis CA. Wang Y, et al. Among authors: debnath ml. J Mol Neurosci. 2002 Aug-Oct;19(1-2):11-6. doi: 10.1007/s12031-002-0004-8. J Mol Neurosci. 2002. PMID: 12212766

3

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.

Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT. Klunk WE, et al. Among authors: debnath ml. J Neuropathol Exp Neurol. 2002 Sep;61(9):797-805. doi: 10.1093/jnen/61.9.797. J Neuropathol Exp Neurol. 2002. PMID: 12230326

4

The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component.

Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Shao L, Hamilton RL, Ikonomovic MD, DeKosky ST, Mathis CA. Klunk WE, et al. Among authors: debnath ml. J Neurosci. 2003 Mar 15;23(6):2086-92. doi: 10.1523/JNEUROSCI.23-06-02086.2003. J Neurosci. 2003. PMID: 12657667 Free PMC article.

5

Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.

Mathis CA, Wang Y, Holt DP, Huang GF, Debnath ML, Klunk WE. Mathis CA, et al. Among authors: debnath ml. J Med Chem. 2003 Jun 19;46(13):2740-54. doi: 10.1021/jm030026b. J Med Chem. 2003. PMID: 12801237

6

Effects of lipophilicity on the affinity and nonspecific binding of iodinated benzothiazole derivatives.

Wang Y, Mathis CA, Huang GF, Debnath ML, Holt DP, Shao L, Klunk WE. Wang Y, et al. Among authors: debnath ml. J Mol Neurosci. 2003;20(3):255-60. doi: 10.1385/JMN:20:3:255. J Mol Neurosci. 2003. PMID: 14501005

7

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.

Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergström M, Savitcheva I, Huang GF, Estrada S, Ausén B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Långström B. Klunk WE, et al. Among authors: debnath ml. Ann Neurol. 2004 Mar;55(3):306-19. doi: 10.1002/ana.20009. Ann Neurol. 2004. PMID: 14991808

8

Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain.

Klunk WE, Lopresti BJ, Ikonomovic MD, Lefterov IM, Koldamova RP, Abrahamson EE, Debnath ML, Holt DP, Huang GF, Shao L, DeKosky ST, Price JC, Mathis CA. Klunk WE, et al. Among authors: debnath ml. J Neurosci. 2005 Nov 16;25(46):10598-606. doi: 10.1523/JNEUROSCI.2990-05.2005. J Neurosci. 2005. PMID: 16291932 Free PMC article.

9

Synthesis and beta-amyloid binding properties of rhenium 2-phenylbenzothiazoles.

Lin KS, Debnath ML, Mathis CA, Klunk WE. Lin KS, et al. Among authors: debnath ml. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2258-62. doi: 10.1016/j.bmcl.2009.02.096. Epub 2009 Feb 27. Bioorg Med Chem Lett. 2009. PMID: 19285394 Free PMC article.

10

Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.

Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Mathis CA. Klunk WE, et al. Among authors: debnath ml. Life Sci. 2001 Aug 17;69(13):1471-84. doi: 10.1016/s0024-3205(01)01232-2. Life Sci. 2001. PMID: 11554609

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