Shi X - Search Results

1

Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.

Mewshaw RE, Meagher KL, Zhou P, Zhou D, Shi X, Scerni R, Smith D, Schechter LE, Andree TH. Mewshaw RE, et al. Among authors: shi x. Bioorg Med Chem Lett. 2002 Feb 11;12(3):307-10. doi: 10.1016/s0960-894x(01)00746-6. Bioorg Med Chem Lett. 2002. PMID: 11814784

2

New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template.

Mewshaw RE, Zhao R, Shi X, Marquis K, Brennan JA, Mazandarani H, Coupet J, Andree TH. Mewshaw RE, et al. Among authors: shi x. Bioorg Med Chem Lett. 2002 Feb 11;12(3):271-4. doi: 10.1016/s0960-894x(01)00778-8. Bioorg Med Chem Lett. 2002. PMID: 11814775

3

Modulation of selective serotonin reuptake inhibitor and 5-HT1A antagonist activity in 8-aza-bicyclo[3.2.1]octane derivatives of 2,3-dihydro-1,4-benzodioxane.

Gilbert AM, Stack GP, Nilakantan R, Kodah J, Tran M, Scerni R, Shi X, Smith DL, Andree TH. Gilbert AM, et al. Among authors: shi x. Bioorg Med Chem Lett. 2004 Jan 19;14(2):515-8. doi: 10.1016/j.bmcl.2003.10.024. Bioorg Med Chem Lett. 2004. PMID: 14698193

4

Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.

Mewshaw RE, Zhou D, Zhou P, Shi X, Hornby G, Spangler T, Scerni R, Smith D, Schechter LE, Andree TH. Mewshaw RE, et al. Among authors: shi x. J Med Chem. 2004 Jul 15;47(15):3823-42. doi: 10.1021/jm0304010. J Med Chem. 2004. PMID: 15239661

5

New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans.

Mewshaw RE, Kavanagh J, Stack G, Marquis KL, Shi X, Kagan MZ, Webb MB, Katz AH, Park A, Kang YH, Abou-Gharbia M, Scerni R, Wasik T, Cortes-Burgos L, Spangler T, Brennan JA, Piesla M, Mazandarani H, Cockett MI, Ochalski R, Coupet J, Andree TH. Mewshaw RE, et al. Among authors: shi x. J Med Chem. 1997 Dec 19;40(26):4235-56. doi: 10.1021/jm9703653. J Med Chem. 1997. PMID: 9435894

6

New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.

Mewshaw RE, Husbands M, Gildersleeve ES, Webb MB, Shi X, Mazandarani H, Cockett MI, Ochalski R, Brennan JA, Abou-Gharbia M, Marquis K, McGaughey GB, Coupet J, Andree TH. Mewshaw RE, et al. Among authors: shi x. Bioorg Med Chem Lett. 1998 Feb 3;8(3):295-300. doi: 10.1016/s0960-894x(98)00014-6. Bioorg Med Chem Lett. 1998. PMID: 9871673

7

New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template.

Mewshaw RE, Verwijs A, Shi X, McGaughey GB, Nelson JA, Mazandarani H, Brennan JA, Marquis KL, Coupet J, Andree TH. Mewshaw RE, et al. Among authors: shi x. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. doi: 10.1016/s0960-894x(98)00474-0. Bioorg Med Chem Lett. 1998. PMID: 9873601

8

New generation dopaminergic agents. 6. Structure-activity relationship studies of a series of 4-(aminoethoxy)indole and 4-(aminoethoxy)indolone derivatives based on the newly discovered 3-hydroxyphenoxyethylamine D2 template.

Mewshaw RE, Webb MB, Marquis KL, McGaughey GB, Shi X, Wasik T, Scerni R, Brennan JA, Andree TH. Mewshaw RE, et al. Among authors: shi x. J Med Chem. 1999 Jun 3;42(11):2007-20. doi: 10.1021/jm990023s. J Med Chem. 1999. PMID: 10354409

9

New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template.

Mewshaw RE, Nelson JA, Shah US, Shi X, Mazandarani H, Coupet J, Marquis K, Brennan JA, Andree TH. Mewshaw RE, et al. Among authors: shi x. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. doi: 10.1016/s0960-894x(99)00434-5. Bioorg Med Chem Lett. 1999. PMID: 10498215

10

Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors.

Meagher KL, Mewshaw RE, Evrard DA, Zhou P, Smith DL, Scerni R, Spangler T, Abulhawa S, Shi X, Schechter LE, Andree TH. Meagher KL, et al. Among authors: shi x. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1885-8. doi: 10.1016/s0960-894x(01)00334-1. Bioorg Med Chem Lett. 2001. PMID: 11459653

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