Rasper D - Search Results

1

The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7.

Maier JK, Lahoua Z, Gendron NH, Fetni R, Johnston A, Davoodi J, Rasper D, Roy S, Slack RS, Nicholson DW, MacKenzie AE. Maier JK, et al. Among authors: rasper d. J Neurosci. 2002 Mar 15;22(6):2035-43. doi: 10.1523/JNEUROSCI.22-06-02035.2002. J Neurosci. 2002. PMID: 11896143 Free PMC article.

2

Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice.

Houde C, Banks KG, Coulombe N, Rasper D, Grimm E, Roy S, Simpson EM, Nicholson DW. Houde C, et al. Among authors: rasper d. J Neurosci. 2004 Nov 3;24(44):9977-84. doi: 10.1523/JNEUROSCI.3356-04.2004. J Neurosci. 2004. PMID: 15525783 Free PMC article.

3

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.

Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW. Gervais FG, et al. Nat Cell Biol. 2002 Feb;4(2):95-105. doi: 10.1038/ncb735. Nat Cell Biol. 2002. PMID: 11788820

4

Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis.

Xanthoudakis S, Roy S, Rasper D, Hennessey T, Aubin Y, Cassady R, Tawa P, Ruel R, Rosen A, Nicholson DW. Xanthoudakis S, et al. Among authors: rasper d. EMBO J. 1999 Apr 15;18(8):2049-56. doi: 10.1093/emboj/18.8.2049. EMBO J. 1999. PMID: 10205159 Free PMC article.

5

Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.

Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J, Tawa P, Nicholson DW, Zamboni RJ. Han Y, et al. Among authors: rasper dm. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80. doi: 10.1016/j.bmcl.2004.12.006. Bioorg Med Chem Lett. 2005. PMID: 15686936

6

Solid phase synthesis of selective caspase-3 peptide inhibitors.

Grimm EL, Roy B, Aspiotis R, Bayly CI, Nicholson DW, Rasper DM, Renaud J, Roy S, Tam J, Tawa P, Vaillancourt JP, Xanthoudakis S, Zamboni RJ. Grimm EL, et al. Among authors: rasper dm. Bioorg Med Chem. 2004 Mar 1;12(5):845-51. doi: 10.1016/j.bmc.2004.01.007. Bioorg Med Chem. 2004. PMID: 14980595

7

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.

Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR. Wellington CL, et al. Among authors: rasper d. J Biol Chem. 1998 Apr 10;273(15):9158-67. doi: 10.1074/jbc.273.15.9158. J Biol Chem. 1998. PMID: 9535906 Free article.

8

HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.

Chopra VS, Metzler M, Rasper DM, Engqvist-Goldstein AE, Singaraja R, Gan L, Fichter KM, McCutcheon K, Drubin D, Nicholson DW, Hayden MR. Chopra VS, et al. Among authors: rasper dm. Mamm Genome. 2000 Nov;11(11):1006-15. doi: 10.1007/s003350010195. Mamm Genome. 2000. PMID: 11063258

9

Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics.

Méthot N, Huang J, Coulombe N, Vaillancourt JP, Rasper D, Tam J, Han Y, Colucci J, Zamboni R, Xanthoudakis S, Toulmond S, Nicholson DW, Roy S. Méthot N, et al. Among authors: rasper d. J Exp Med. 2004 Jan 19;199(2):199-207. doi: 10.1084/jem.20031791. Epub 2004 Jan 12. J Exp Med. 2004. PMID: 14718517 Free PMC article.

10

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.

Goldberg YP, Nicholson DW, Rasper DM, Kalchman MA, Koide HB, Graham RK, Bromm M, Kazemi-Esfarjani P, Thornberry NA, Vaillancourt JP, Hayden MR. Goldberg YP, et al. Among authors: rasper dm. Nat Genet. 1996 Aug;13(4):442-9. doi: 10.1038/ng0896-442. Nat Genet. 1996. PMID: 8696339

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