Pugsley T - Search Results

1

Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.

Böhme TM, Augelli-Szafran CE, Hallak H, Pugsley T, Serpa K, Schwarz RD. Böhme TM, et al. Among authors: pugsley t. J Med Chem. 2002 Jul 4;45(14):3094-102. doi: 10.1021/jm011116o. J Med Chem. 2002. PMID: 12086495

2

Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907).

van Vliet LA, Rodenhuis N, Dijkstra D, Wikström H, Pugsley TA, Serpa KA, Meltzer LT, Heffner TG, Wise LD, Lajiness ME, Huff RM, Svensson K, Sundell S, Lundmark M. van Vliet LA, et al. Among authors: pugsley ta. J Med Chem. 2000 Jul 27;43(15):2871-82. doi: 10.1021/jm0000113. J Med Chem. 2000. PMID: 10956195

3

Design, synthesis, and evaluation of chromen-2-ones as potent and selective human dopamine D4 antagonists.

Kesten SR, Heffner TG, Johnson SJ, Pugsley TA, Wright JL, Wise LD. Kesten SR, et al. Among authors: pugsley ta. J Med Chem. 1999 Sep 9;42(18):3718-25. doi: 10.1021/jm990266k. J Med Chem. 1999. PMID: 10479303

4

Thiazoloindans and thiazolobenzopyrans: a novel class of orally active central dopamine (partial) agonists.

van Vliet LA, Rodenhuis N, Wikström H, Pugsley TA, Serpa KA, Meltzer LT, Heffner TG, Wise LD, Lajiness ME, Huff RM, Svensson K, Haenen GR, Bast A. van Vliet LA, et al. Among authors: pugsley ta. J Med Chem. 2000 Sep 21;43(19):3549-57. doi: 10.1021/jm000087z. J Med Chem. 2000. PMID: 11000009

5

Loss of muscarinic M1 receptors with aging in the cerebral cortex of Fisher 344 rats.

Schwarz RD, Bernabei AA, Spencer CJ, Pugsley TA. Schwarz RD, et al. Among authors: pugsley ta. Pharmacol Biochem Behav. 1990 Mar;35(3):589-93. doi: 10.1016/0091-3057(90)90295-s. Pharmacol Biochem Behav. 1990. PMID: 2339151

6

Chromeno[3,4-c]pyridin-5-ones: selective human dopamine D4 receptor antagonists as potential antipsychotic agents.

Unangst PC, Capiris T, Connor DT, Heffner TG, MacKenzie RG, Miller SR, Pugsley TA, Wise LD. Unangst PC, et al. Among authors: pugsley ta. J Med Chem. 1997 Aug 15;40(17):2688-93. doi: 10.1021/jm970170v. J Med Chem. 1997. PMID: 9276014

7

(Aryloxy)alkylamines as selective human dopamine D4 receptor antagonists: potential antipsychotic agents.

Unangst PC, Capiris T, Connor DT, Doubleday R, Heffner TG, MacKenzie RG, Miller SR, Pugsley TA, Wise LD. Unangst PC, et al. Among authors: pugsley ta. J Med Chem. 1997 Dec 5;40(25):4026-9. doi: 10.1021/jm970422s. J Med Chem. 1997. PMID: 9406594

8

Aminopyrimidines with high affinity for both serotonin and dopamine receptors.

Wustrow D, Belliotti T, Glase S, Kesten SR, Johnson D, Colbry N, Rubin R, Blackburn A, Akunne H, Corbin A, Davis MD, Georgic L, Whetzel S, Zoski K, Heffner T, Pugsley T, Wise L. Wustrow D, et al. Among authors: pugsley t. J Med Chem. 1998 Feb 26;41(5):760-71. doi: 10.1021/jm9707378. J Med Chem. 1998. PMID: 9513604

9

Pharmacological profile of the dopamine partial agonist, (+/-)-PD 128483 and its enantiomers.

Meltzer LT, Caprathe BW, Christoffersen CL, Corbin AE, Jaen JC, Ninteman FW, Pugsley TA, Serpa KA, Shih YH, Whetzel SZ, et al. Meltzer LT, et al. Among authors: pugsley ta. J Pharmacol Exp Ther. 1993 Sep;266(3):1177-89. J Pharmacol Exp Ther. 1993. PMID: 8103791

10

3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists.

Konkel MJ, Lagu B, Boteju LW, Jimenez H, Noble S, Walker MW, Chandrasena G, Blackburn TP, Nikam SS, Wright JL, Kornberg BE, Gregory T, Pugsley TA, Akunne H, Zoski K, Wise LD. Konkel MJ, et al. Among authors: pugsley ta. J Med Chem. 2006 Jun 29;49(13):3757-8. doi: 10.1021/jm060001n. J Med Chem. 2006. PMID: 16789730

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