Terasaka T - Search Results

1

Structure-based de novo design of non-nucleoside adenosine deaminase inhibitors.

Terasaka T, Nakanishi I, Nakamura K, Eikyu Y, Kinoshita T, Nishio N, Sato A, Kuno M, Seki N, Sakane K. Terasaka T, et al. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1115-8. doi: 10.1016/s0960-894x(03)00026-x. Bioorg Med Chem Lett. 2003. PMID: 12643924

2

A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization.

Terasaka T, Kinoshita T, Kuno M, Nakanishi I. Terasaka T, et al. J Am Chem Soc. 2004 Jan 14;126(1):34-5. doi: 10.1021/ja038606l. J Am Chem Soc. 2004. PMID: 14709046

3

Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors.

Terasaka T, Okumura H, Tsuji K, Kato T, Nakanishi I, Kinoshita T, Kato Y, Kuno M, Seki N, Naoe Y, Inoue T, Tanaka K, Nakamura K. Terasaka T, et al. J Med Chem. 2004 May 20;47(11):2728-31. doi: 10.1021/jm0499559. J Med Chem. 2004. PMID: 15139750

4

Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors.

Terasaka T, Kinoshita T, Kuno M, Seki N, Tanaka K, Nakanishi I. Terasaka T, et al. J Med Chem. 2004 Jul 15;47(15):3730-43. doi: 10.1021/jm0306374. J Med Chem. 2004. PMID: 15239652

5

Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism.

Terasaka T, Tsuji K, Kato T, Nakanishi I, Kinoshita T, Kato Y, Kuno M, Inoue T, Tanaka K, Nakamura K. Terasaka T, et al. J Med Chem. 2005 Jul 28;48(15):4750-3. doi: 10.1021/jm050413g. J Med Chem. 2005. PMID: 16033254

6

Structural basis of compound recognition by adenosine deaminase.

Kinoshita T, Nakanishi I, Terasaka T, Kuno M, Seki N, Warizaya M, Matsumura H, Inoue T, Takano K, Adachi H, Mori Y, Fujii T. Kinoshita T, et al. Among authors: terasaka t. Biochemistry. 2005 Aug 9;44(31):10562-9. doi: 10.1021/bi050529e. Biochemistry. 2005. PMID: 16060665

7

Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938.

Kuno M, Seki N, Tsujimoto S, Nakanishi I, Kinoshita T, Nakamura K, Terasaka T, Nishio N, Sato A, Fujii T. Kuno M, et al. Among authors: terasaka t. Eur J Pharmacol. 2006 Mar 18;534(1-3):241-9. doi: 10.1016/j.ejphar.2006.01.042. Epub 2006 Mar 3. Eur J Pharmacol. 2006. PMID: 16515782

8

Discovery of ASP5878: Synthesis and structure-activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity.

Kuriwaki I, Kameda M, Iikubo K, Hisamichi H, Kawamoto Y, Kikuchi S, Moritomo H, Terasaka T, Iwai Y, Noda A, Tomiyama H, Kikuchi A, Hirano M. Kuriwaki I, et al. Among authors: terasaka t. Bioorg Med Chem. 2022 Apr 1;59:116657. doi: 10.1016/j.bmc.2022.116657. Epub 2022 Feb 11. Bioorg Med Chem. 2022. PMID: 35219181

9

Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency.

Kuriwaki I, Kameda M, Iikubo K, Hisamichi H, Kawamoto Y, Kikuchi S, Moritomo H, Kondoh Y, Terasaka T, Amano Y, Tateishi Y, Echizen Y, Iwai Y, Noda A, Tomiyama H, Nakazawa T, Hirano M. Kuriwaki I, et al. Among authors: terasaka t. Bioorg Med Chem. 2021 Mar 1;33:116019. doi: 10.1016/j.bmc.2021.116019. Epub 2021 Jan 16. Bioorg Med Chem. 2021. PMID: 33486159

10

Discovery of novel and potent CRTH2 antagonists.

Ito S, Terasaka T, Zenkoh T, Matsuda H, Hayashida H, Nagata H, Imamura Y, Kobayashi M, Takeuchi M, Ohta M. Ito S, et al. Among authors: terasaka t. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1194-7. doi: 10.1016/j.bmcl.2011.11.079. Epub 2011 Nov 28. Bioorg Med Chem Lett. 2012. PMID: 22178554

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