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HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects.
Adv Cancer Res. 2003;88:1-29. doi: 10.1016/s0065-230x(03)88302-1.
Adv Cancer Res. 2003.
PMID: 12665051
Review.
Hamlet--a complex from human milk that induces apoptosis in tumor cells but spares healthy cells.
Svensson M, Düringer C, Hallgren O, Mossberg AK, Håkansson A, Linse S, Svanborg C.
Svensson M, et al. Among authors: duringer c.
Adv Exp Med Biol. 2002;503:125-32. doi: 10.1007/978-1-4615-0559-4_14.
Adv Exp Med Biol. 2002.
PMID: 12026011
Review.
No abstract available.
Item in Clipboard
HAMLET interacts with histones and chromatin in tumor cell nuclei.
Düringer C, Hamiche A, Gustafsson L, Kimura H, Svanborg C.
Düringer C, et al.
J Biol Chem. 2003 Oct 24;278(43):42131-5. doi: 10.1074/jbc.M306462200. Epub 2003 Jul 29.
J Biol Chem. 2003.
PMID: 12888554
Free article.
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Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).
Svensson M, Fast J, Mossberg AK, Düringer C, Gustafsson L, Hallgren O, Brooks CL, Berliner L, Linse S, Svanborg C.
Svensson M, et al. Among authors: duringer c.
Protein Sci. 2003 Dec;12(12):2794-804. doi: 10.1110/ps.0231003.
Protein Sci. 2003.
PMID: 14627739
Free PMC article.
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Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET.
Brest P, Gustafsson M, Mossberg AK, Gustafsson L, Duringer C, Hamiche A, Svanborg C.
Brest P, et al. Among authors: duringer c.
Cancer Res. 2007 Dec 1;67(23):11327-34. doi: 10.1158/0008-5472.CAN-07-1153.
Cancer Res. 2007.
PMID: 18056459
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Agonist-specific patterns of beta 2-adrenoceptor responses in human airway cells during prolonged exposure.
Düringer C, Grundström G, Gürcan E, Dainty IA, Lawson M, Korn SH, Jerre A, Håkansson HF, Wieslander E, Fredriksson K, Sköld CM, Löfdahl M, Löfdahl CG, Nicholls DJ, Silberstein DS.
Düringer C, et al.
Br J Pharmacol. 2009 Sep;158(1):169-79. doi: 10.1111/j.1476-5381.2009.00262.x. Epub 2009 Jun 22.
Br J Pharmacol. 2009.
PMID: 19558544
Free PMC article.
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