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CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.
Tippin TK, Hamilton G, Moore L, Beaudet EJ, Jolley S, Brodie TA, Andrews RC, Becherer JD, McDougald DL, Gaul MD, Hoivik DJ, Mellon-Kusibab K, Lehmann J, Kliewer S, Novick S, Laethem R, Zhao Z, LeCluyse EL. Tippin TK, et al. Among authors: zhao z. Drug Metab Dispos. 2003 Jul;31(7):870-7. doi: 10.1124/dmd.31.7.870. Drug Metab Dispos. 2003. PMID: 12814963
Fibrates induce hepatic peroxisome and mitochondrial proliferation without overt evidence of cellular proliferation and oxidative stress in cynomolgus monkeys.
Hoivik DJ, Qualls CW Jr, Mirabile RC, Cariello NF, Kimbrough CL, Colton HM, Anderson SP, Santostefano MJ, Morgan RJ, Dahl RR, Brown AR, Zhao Z, Mudd PN Jr, Oliver WB Jr, Brown HR, Miller RT. Hoivik DJ, et al. Among authors: zhao z. Carcinogenesis. 2004 Sep;25(9):1757-69. doi: 10.1093/carcin/bgh182. Epub 2004 May 6. Carcinogenesis. 2004. PMID: 15131011
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