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Structure/function of human type 1 3beta-hydroxysteroid dehydrogenase: An intrasubunit disulfide bond in the Rossmann-fold domain and a Cys residue in the active site are critical for substrate and coenzyme utilization.
Thomas JL, Huether R, Mack VL, Scaccia LA, Stoner RC, Duax WL. Thomas JL, et al. Among authors: duax wl. J Steroid Biochem Mol Biol. 2007 Oct;107(1-2):80-7. doi: 10.1016/j.jsbmb.2007.02.003. Epub 2007 May 25. J Steroid Biochem Mol Biol. 2007. PMID: 17624763 Free PMC article.
Rational proteomics V: structure-based mutagenesis has revealed key residues responsible for substrate recognition and catalysis by the dehydrogenase and isomerase activities in human 3beta-hydroxysteroid dehydrogenase/isomerase type 1.
Pletnev VZ, Thomas JL, Rhaney FL, Holt LS, Scaccia LA, Umland TC, Duax WL. Pletnev VZ, et al. Among authors: duax wl. J Steroid Biochem Mol Biol. 2006 Sep;101(1):50-60. doi: 10.1016/j.jsbmb.2006.06.004. Epub 2006 Aug 4. J Steroid Biochem Mol Biol. 2006. PMID: 16889958 Free PMC article.
145 results