Kaupmann K - Search Results

1

N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.

Urwyler S, Pozza MF, Lingenhoehl K, Mosbacher J, Lampert C, Froestl W, Koller M, Kaupmann K. Urwyler S, et al. Among authors: kaupmann k. J Pharmacol Exp Ther. 2003 Oct;307(1):322-30. doi: 10.1124/jpet.103.053074. Epub 2003 Sep 3. J Pharmacol Exp Ther. 2003. PMID: 12954816

2

Selected amino acids, dipeptides and arylalkylamine derivatives do not act as allosteric modulators at GABAB receptors.

Urwyler S, Gjoni T, Kaupmann K, Pozza MF, Mosbacher J. Urwyler S, et al. Among authors: kaupmann k. Eur J Pharmacol. 2004 Jan 12;483(2-3):147-53. doi: 10.1016/j.ejphar.2003.10.024. Eur J Pharmacol. 2004. PMID: 14729102

3

Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines.

Cryan JF, Kelly PH, Chaperon F, Gentsch C, Mombereau C, Lingenhoehl K, Froestl W, Bettler B, Kaupmann K, Spooren WP. Cryan JF, et al. Among authors: kaupmann k. J Pharmacol Exp Ther. 2004 Sep;310(3):952-63. doi: 10.1124/jpet.104.066753. Epub 2004 Apr 27. J Pharmacol Exp Ther. 2004. PMID: 15113848

4

Point mutations in the transmembrane region of GABAB2 facilitate activation by the positive modulator N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the absence of the GABAB1 subunit.

Dupuis DS, Relkovic D, Lhuillier L, Mosbacher J, Kaupmann K. Dupuis DS, et al. Among authors: kaupmann k. Mol Pharmacol. 2006 Dec;70(6):2027-36. doi: 10.1124/mol.106.028183. Epub 2006 Sep 11. Mol Pharmacol. 2006. PMID: 16966477

5

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Guery S, Floersheim P, Kaupmann K, Froestl W. Guery S, et al. Among authors: kaupmann k. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6206-11. doi: 10.1016/j.bmcl.2007.09.023. Epub 2007 Sep 8. Bioorg Med Chem Lett. 2007. PMID: 17884493 Free PMC article.

6

Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501.

Urwyler S, Mosbacher J, Lingenhoehl K, Heid J, Hofstetter K, Froestl W, Bettler B, Kaupmann K. Urwyler S, et al. Among authors: kaupmann k. Mol Pharmacol. 2001 Nov;60(5):963-71. Mol Pharmacol. 2001. PMID: 11641424

7

Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice.

Kaupmann K, Cryan JF, Wellendorph P, Mombereau C, Sansig G, Klebs K, Schmutz M, Froestl W, van der Putten H, Mosbacher J, Bräuner-Osborne H, Waldmeier P, Bettler B. Kaupmann K, et al. Eur J Neurosci. 2003 Nov;18(10):2722-30. doi: 10.1111/j.1460-9568.2003.03013.x. Eur J Neurosci. 2003. PMID: 14656321

8

Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior.

Mombereau C, Kaupmann K, Froestl W, Sansig G, van der Putten H, Cryan JF. Mombereau C, et al. Among authors: kaupmann k. Neuropsychopharmacology. 2004 Jun;29(6):1050-62. doi: 10.1038/sj.npp.1300413. Neuropsychopharmacology. 2004. PMID: 15039762

9

Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats.

Paterson NE, Vlachou S, Guery S, Kaupmann K, Froestl W, Markou A. Paterson NE, et al. Among authors: kaupmann k. J Pharmacol Exp Ther. 2008 Jul;326(1):306-14. doi: 10.1124/jpet.108.139204. Epub 2008 Apr 29. J Pharmacol Exp Ther. 2008. PMID: 18445779 Free PMC article.

10

Roles of GABAB receptor subtypes in presynaptic auto- and heteroreceptor function regulating GABA and glutamate release.

Waldmeier PC, Kaupmann K, Urwyler S. Waldmeier PC, et al. Among authors: kaupmann k. J Neural Transm (Vienna). 2008 Oct;115(10):1401-11. doi: 10.1007/s00702-008-0095-7. Epub 2008 Jul 30. J Neural Transm (Vienna). 2008. PMID: 18665320 Free article.

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