A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives.
Sullivan V, Biron KK, Talarico C, Stanat SC, Davis M, Pozzi LM, Coen DM.
Sullivan V, et al. Among authors: davis m.
Antimicrob Agents Chemother. 1993 Jan;37(1):19-25. doi: 10.1128/AAC.37.1.19.
Antimicrob Agents Chemother. 1993.
PMID: 8381637
Free PMC article.
Ganciclovir-resistant mutant 759rD100 derived from human cytomegalovirus strain AD169 contains two resistance mutations, one of which is in the UL97 gene and results in decreased ganciclovir phosphorylation in infected cells [V. Sullivan, C. L. Talarico, S. C. Stanat, M. …
Ganciclovir-resistant mutant 759rD100 derived from human cytomegalovirus strain AD169 contains two resistance mutations, one of which is in …