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New orally active PDE4 inhibitors with therapeutic potential.
Ochiai H, Ishida A, Ohtani T, Kusumi K, Kishikawa K, Obata T, Nakai H, Toda M. Ochiai H, et al. Among authors: obata t. Bioorg Med Chem Lett. 2004 Jan 5;14(1):29-32. doi: 10.1016/j.bmcl.2003.10.025. Bioorg Med Chem Lett. 2004. PMID: 14684291
Highly potent inhibitors of TNF-alpha production. Part II: metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer.
Matsui T, Kondo T, Nishita Y, Itadani S, Tsuruta H, Fujita S, Omawari N, Sakai M, Nakazawa S, Ogata A, Mori H, Kamoshima W, Terai K, Ohno H, Obata T, Nakai H, Toda M. Matsui T, et al. Among authors: obata t. Bioorg Med Chem. 2002 Dec;10(12):3787-805. doi: 10.1016/s0968-0896(02)00380-2. Bioorg Med Chem. 2002. PMID: 12413833
Highly potent PDE4 inhibitors with therapeutic potential.
Ochiai H, Ohtani T, Ishida A, Kusumi K, Kato M, Kohno H, Kishikawa K, Obata T, Nakai H, Toda M. Ochiai H, et al. Among authors: obata t. Bioorg Med Chem Lett. 2004 Jan 5;14(1):207-10. doi: 10.1016/j.bmcl.2003.09.087. Bioorg Med Chem Lett. 2004. PMID: 14684329
Orally active PDE4 inhibitors with therapeutic potential.
Ochiai H, Ohtani T, Ishida A, Kishikawa K, Obata T, Nakai H, Toda M. Ochiai H, et al. Among authors: obata t. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1323-7. doi: 10.1016/j.bmcl.2003.12.018. Bioorg Med Chem Lett. 2004. PMID: 14980691
Orally active PDE4 inhibitor with therapeutic potential.
Ochiai H, Ohtani T, Ishida A, Kishikawa K, Yamamoto S, Takeda H, Obata T, Nakai H, Toda M. Ochiai H, et al. Among authors: obata t. Eur J Med Chem. 2004 Jul;39(7):555-71. doi: 10.1016/j.ejmech.2004.02.010. Eur J Med Chem. 2004. PMID: 15236836
New orally active PDE4 inhibitors with therapeutic potential.
Ochiai H, Ishida A, Ohtani T, Kusumi K, Kishikawa K, Yamamoto S, Takeda H, Obata T, Nakai H, Toda M. Ochiai H, et al. Among authors: obata t. Bioorg Med Chem. 2004 Aug 1;12(15):4089-100. doi: 10.1016/j.bmc.2004.05.032. Bioorg Med Chem. 2004. PMID: 15246087
781 results