Wynn TA - Search Results

1

IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis.

Mentink-Kane MM, Cheever AW, Thompson RW, Hari DM, Kabatereine NB, Vennervald BJ, Ouma JH, Mwatha JK, Jones FM, Donaldson DD, Grusby MJ, Dunne DW, Wynn TA. Mentink-Kane MM, et al. Among authors: wynn ta. Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):586-90. doi: 10.1073/pnas.0305064101. Epub 2003 Dec 29. Proc Natl Acad Sci U S A. 2004. PMID: 14699044 Free PMC article.

2

Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.

Oswald IP, Wynn TA, Sher A, James SL. Oswald IP, et al. Among authors: wynn ta. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8676-80. doi: 10.1073/pnas.89.18.8676. Proc Natl Acad Sci U S A. 1992. PMID: 1528880 Free PMC article.

3

Cytokine regulation of granuloma formation in schistosomiasis.

Wynn TA, Cheever AW. Wynn TA, et al. Curr Opin Immunol. 1995 Aug;7(4):505-11. doi: 10.1016/0952-7915(95)80095-6. Curr Opin Immunol. 1995. PMID: 7495514 Review.

4

Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide.

Oswald IP, Eltoum I, Wynn TA, Schwartz B, Caspar P, Paulin D, Sher A, James SL. Oswald IP, et al. Among authors: wynn ta. Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):999-1003. doi: 10.1073/pnas.91.3.999. Proc Natl Acad Sci U S A. 1994. PMID: 7508126 Free PMC article.

5

An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection.

Wynn TA, Cheever AW, Jankovic D, Poindexter RW, Caspar P, Lewis FA, Sher A. Wynn TA, et al. Nature. 1995 Aug 17;376(6541):594-6. doi: 10.1038/376594a0. Nature. 1995. PMID: 7637808

6

IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma.

Wynn TA, Jankovic D, Hieny S, Zioncheck K, Jardieu P, Cheever AW, Sher A. Wynn TA, et al. J Immunol. 1995 Apr 15;154(8):3999-4009. J Immunol. 1995. PMID: 7706739

7

IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia.

Wynn TA, Jankovic D, Hieny S, Cheever AW, Sher A. Wynn TA, et al. J Immunol. 1995 May 1;154(9):4701-9. J Immunol. 1995. PMID: 7722323

8

Suppressive effect of interleukin-4 neutralization differs for granulomas around Schistosoma mansoni eggs injected into mice compared with those around eggs laid in infected mice.

Eltoum IA, Wynn TA, Poindexter RW, Finkelman FD, Lewis FA, Sher A, Cheever AW. Eltoum IA, et al. Among authors: wynn ta. Infect Immun. 1995 Jul;63(7):2532-6. doi: 10.1128/iai.63.7.2532-2536.1995. Infect Immun. 1995. PMID: 7790066 Free PMC article.

9

Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology.

Wynn TA, Eltoum I, Oswald IP, Cheever AW, Sher A. Wynn TA, et al. J Exp Med. 1994 May 1;179(5):1551-61. doi: 10.1084/jem.179.5.1551. J Exp Med. 1994. PMID: 7909326 Free PMC article.

10

Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

Cheever AW, Williams ME, Wynn TA, Finkelman FD, Seder RA, Cox TM, Hieny S, Caspar P, Sher A. Cheever AW, et al. Among authors: wynn ta. J Immunol. 1994 Jul 15;153(2):753-9. J Immunol. 1994. PMID: 8021510

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