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Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002).
Bakker J, Grover R, McLuckie A, Holzapfel L, Andersson J, Lodato R, Watson D, Grossman S, Donaldson J, Takala J; Glaxo Wellcome International Septic Shock Study Group. Bakker J, et al. Among authors: holzapfel l. Crit Care Med. 2004 Jan;32(1):1-12. doi: 10.1097/01.CCM.0000105118.66983.19. Crit Care Med. 2004. PMID: 14707554 Clinical Trial.
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock.
López A, Lorente JA, Steingrub J, Bakker J, McLuckie A, Willatts S, Brockway M, Anzueto A, Holzapfel L, Breen D, Silverman MS, Takala J, Donaldson J, Arneson C, Grove G, Grossman S, Grover R. López A, et al. Among authors: holzapfel l. Crit Care Med. 2004 Jan;32(1):21-30. doi: 10.1097/01.CCM.0000105581.01815.C6. Crit Care Med. 2004. PMID: 14707556 Clinical Trial.
Confirmatory platelet-activating factor receptor antagonist trial in patients with severe gram-negative bacterial sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. BN 52021 Sepsis Investigator Group.
Dhainaut JF, Tenaillon A, Hemmer M, Damas P, Le Tulzo Y, Radermacher P, Schaller MD, Sollet JP, Wolff M, Holzapfel L, Zeni F, Vedrinne JM, de Vathaire F, Gourlay ML, Guinot P, Mira JP. Dhainaut JF, et al. Among authors: holzapfel l. Crit Care Med. 1998 Dec;26(12):1963-71. doi: 10.1097/00003246-199812000-00021. Crit Care Med. 1998. PMID: 9875905 Clinical Trial.
Nadroparin in the prevention of deep vein thrombosis in acute decompensated COPD. The Association of Non-University Affiliated Intensive Care Specialist Physicians of France.
Fraisse F, Holzapfel L, Couland JM, Simonneau G, Bedock B, Feissel M, Herbecq P, Pordes R, Poussel JF, Roux L. Fraisse F, et al. Among authors: holzapfel l. Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1109-14. doi: 10.1164/ajrccm.161.4.9807025. Am J Respir Crit Care Med. 2000. PMID: 10764298 Clinical Trial.
Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients.
Blot F, Similowski T, Trouillet JL, Chardon P, Korach JM, Costa MA, Journois D, Thiéry G, Fartoukh M, Pipien I, Bruder N, Orlikowski D, Tankere F, Durand-Zaleski I, Auboyer C, Nitenberg G, Holzapfel L, Tenaillon A, Chastre J, Laplanche A. Blot F, et al. Among authors: holzapfel l. Intensive Care Med. 2008 Oct;34(10):1779-87. doi: 10.1007/s00134-008-1195-4. Epub 2008 Jul 1. Intensive Care Med. 2008. PMID: 18592210 Clinical Trial.
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