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Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.
Tarnchompoo B, Sirichaiwat C, Phupong W, Intaraudom C, Sirawaraporn W, Kamchonwongpaisan S, Vanichtanankul J, Thebtaranonth Y, Yuthavong Y. Tarnchompoo B, et al. Among authors: intaraudom c. J Med Chem. 2002 Mar 14;45(6):1244-52. doi: 10.1021/jm010131q. J Med Chem. 2002. PMID: 11881993
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