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Page 1
SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction.
Pissarnitski DA, Asberom T, Boyle CD, Chackalamannil S, Chintala M, Clader JW, Greenlee WJ, Hu Y, Kurowski S, Myers J, Palamanda J, Stamford AW, Vemulapalli S, Wang Y, Wang P, Wu P, Xu R. Pissarnitski DA, et al. Among authors: boyle cd. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1291-4. doi: 10.1016/j.bmcl.2003.12.027. Bioorg Med Chem Lett. 2004. PMID: 14980684
Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors.
Wang Y, Chackalamannil S, Hu Z, Boyle CD, Lankin CM, Xia Y, Xu R, Asberom T, Pissarnitski D, Stamford AW, Greenlee WJ, Skell J, Kurowski S, Vemulapalli S, Palamanda J, Chintala M, Wu P, Myers J, Wang P. Wang Y, et al. Among authors: boyle cd. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3149-52. doi: 10.1016/s0960-894x(02)00646-7. Bioorg Med Chem Lett. 2002. PMID: 12372521
Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED.
Boyle CD, Xu R, Asberom T, Chackalamannil S, Clader JW, Greenlee WJ, Guzik H, Hu Y, Hu Z, Lankin CM, Pissarnitski DA, Stamford AW, Wang Y, Skell J, Kurowski S, Vemulapalli S, Palamanda J, Chintala M, Wu P, Myers J, Wang P. Boyle CD, et al. Bioorg Med Chem Lett. 2005 May 2;15(9):2365-9. doi: 10.1016/j.bmcl.2005.02.083. Bioorg Med Chem Lett. 2005. PMID: 15837326
The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors.
Neelamkavil SF, Boyle CD, Chackalamannil S, Greenlee WJ, Zhang L, Terracina G. Neelamkavil SF, et al. Among authors: boyle cd. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4563-5. doi: 10.1016/j.bmcl.2009.07.003. Epub 2009 Jul 8. Bioorg Med Chem Lett. 2009. PMID: 19625185
Discovery of MK-8282 as a Potent G-Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes.
Neelamkavil SF, Stamford AW, Kowalski T, Biswas D, Boyle C, Chackalamannil S, Xia Y, Jayne C, Neustadt B, Hao J, Liu H, Dai X, Baker H, Hawes B, O'Neill K, Tang H, Greenlee WJ. Neelamkavil SF, et al. ACS Med Chem Lett. 2018 Apr 10;9(5):457-461. doi: 10.1021/acsmedchemlett.8b00073. eCollection 2018 May 10. ACS Med Chem Lett. 2018. PMID: 29795759 Free PMC article.
Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification.
Boyle CD, Vice SF, Campion J, Chackalamannil S, Lankin CM, McCombie SW, Billard W, Binch H 3rd, Crosby G, Williams MC, Coffin VL, Cox KA, Grotz DE, Duffy RA, Ruperto V, Lachowicz JE. Boyle CD, et al. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3479-82. doi: 10.1016/s0960-894x(02)00742-4. Bioorg Med Chem Lett. 2002. PMID: 12419388
Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists.
Wang Y, Chackalamannil S, Hu Z, Greenlee WJ, Clader J, Boyle CD, Kaminski JJ, Billard W, Binch H 3rd, Crosby G, Ruperto V, Duffy RA, Cohen-Williams M, Coffin VL, Cox KA, Grotz DE, Lachowicz JE. Wang Y, et al. Among authors: boyle cd. J Med Chem. 2002 Dec 5;45(25):5415-8. doi: 10.1021/jm0255163. J Med Chem. 2002. PMID: 12459007
Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors.
Shah U, Boyle CD, Chackalamannil S, Baker H, Kowalski T, Lee J, Terracina G, Zhang L. Shah U, et al. Among authors: boyle cd. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1551-4. doi: 10.1016/j.bmcl.2010.01.082. Epub 2010 Jan 25. Bioorg Med Chem Lett. 2010. PMID: 20149650
22 results